4- Quinolinemethanol derivatives

Patent 4-Quinolinemethanol Derivatives as Purine Receptor Antagonists... 

Piperidyl- and adamantly-4-quinolinemethanol derivatives of the current invention have been prepared and are discussed (3). 

Mefloquine (14), a 4-quinolinemethanol derivative with attached 2-piperidyl and 2,8 bis-(trifluoromethyl) groups arose from a synthetic effort on 4-quinolinemethanol. This compound possesses activity against murine malaria and is clinically effective against chloroquine-resistant strains of P. falciparum. 

Quinine, was the first known antimalarial. It is a 4-quinolinemethanol derivative bearing a substituted quinuclidine ring. The use of quinine in Europe began in the seventeenth century, after the Incas of Peru informed the Spanish Jesuits about the antimalarial properties of the bark of an... 

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