PYY-preferring receptor

Y2 receptors were originally cloned from human SMS-KAN cells. Later cloning studies in rats demonstrated that the cloned Y2 receptor is also the molecular correlate of a previously proposed PYY-preferring receptor in the gastrointestinal tract. Messenger RNA for the Y2 receptor has been detected in various parts of the CNS, whereas only low levels of Y2 mRNA were found in human peripheral tissues. 

A PYY-preferring receptor has been described in the small intestine by the modest preference for PYY over NPY (5-10-fold) (Laburthe et al., 1986). As this receptor binds centrally truncated analogues, such as [Ahx5-24]NPY (Beck-Sickinger et al., unpublished), this receptor might be a Y2-receptor-like subtype. 

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