Lipidic receptors

Amino acid receptors Monoamine receptors Lipid receptors Purine receptors Neuropeptide receptors Peptide hormone receptors Chemokine receptors Glycoprotein receptors Protease receptors Metabotropic glutamate and GABAb receptors Adrenoceptors, dopamine and 5-HT receptors, muscarinic and histamine receptors Prostaglandin, thromboxane and PAF receptors Adenosine and ATP (P2Y) receptors Neuropeptide Y, opiate, cholecystokinin VIP, etc. Angiotensin, bradykinin, glucagon, calcitonin, parathyroid, etc. Interleukin-8 TSH, LH/FSH, chorionic gonadotropin, etc. Thrombin... 

This brief literature review provides compelling evidence in favour of a significant role for the sense of taste in fat preference in rodents. However, the presence of several putative lipid receptors (CD36, Kvl.5 channels, GPR120) in taste buds was not expected and raises questions about the physiological roles of these receptors. Furthermore, the taste-mediated perception of LCFA by CD36 would be unusual owing to the multifunctional nature of this protein. 

Lipid Receptor Activate Inhibit Cell Type In Vivo References... 

Lobo, M.V., Huerta, L., Ruiz-Velasco, N., Teixeiro, E., de la Cueva, P., Celdran, A., Martin-Hidalgo, A., Vega, M.A. Bragado, R. Localization of the lipid receptors CD36 and CLA-l/SR-BI in the human gastrointestinal tract towards the identification of receptors mediating the intestinal absorption of dietary lipids. J. Histochem. Cytochem. 2001, 49 1253-1260. 

Qian M, Cai D, Veihey KJ, Tsai B (2009) A lipid receptor sorts polyomavirus from the endolysosome to the cuidoplasmic reticulum to cause infection. PLoS Pathog 5 el000465... 

If is anofher example of the use of a dual lipid/receptor system. In Chapter 12, we will show that HIV-1 use both gangliosides and cholesterol in conjunction with the fusion coreceptor CCR5 to gain entry into brain cells. In this case, the dual system becomes a trio, yet the overall mechanism remains the same lipid-assisted delivery of extracellular compounds to high-affinity receptors. 

After these concrete examples of lipid-receptor interactions, the reader will not be surprised that the lipid composition of cells used for heterologous expression of membrane proteins is a critical issue. As summarized in Fig. 7.10, lipids exert a fine control of receptor function through direct lipid-protein interactions. Moreover, specific lipid-lipid interactions might be required to transform structural yet "inert" lipids into regulatory lipids able to modulate receptor conformation and function. For instance, cholesterol programs sphingolipids in such a way that they acquire a specific conformation, which in turn is recognized by the receptor. 

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