Contemporary drug discovery

Mitscher, L.A. and Dutta A., 2006, Contemporary drug discovery. In Chorghade, M.S., (Ed), Drug discovery and development Volume I, Drug discovery, Wiley-Interscience. 103-128. 

Psychotomimetic drugs biochemistry and pharmacology. 7. 165 Purine receptors and their pharmacological roles, 18. 292 The Rate of contemporary drug discovery. 8. I Recent /3-adrenoreceptor stimulants. 5. 197... 

TA Baillie, PG Pearson. The impact of drug metabolism in contemporary drug discovery new opportunities and challenges for mass spectrometry. In AL Burlingame, SA Can, MA Baldwin, eds. Mass Spectrometry in Biology and Medicine. Totowa, NJ Humana Press, 1999. 

Mitscher, L. A., Sc Dutta, A. (2006). Contemporary drug discovery. In M. S. Chorghade (Ed.), Drug Discovery and Development Volume 1 Drug Discovery (pp. 103—128). Hoboken, NJ John Wiley Sc Sons. 

This chapter consists of four main sections. The first provides an overall description of the process of contemporary protein structure determination by X-ray crystallography and summarizes the current computational requirements. This is followed by a summary and examples of the use of structure-based methods in drug discovery. The third section reviews the key developments in computer hardware and computational methods that have supported the development and application of X-ray crystallography over the past forty or so years. The final section outlines the areas in which improved... 

The chapters presented in this book have been contributed by specialists in their areas of research and will provide a contemporary picture of the overall field of drug discovery to scientists from diverse disciplines. 

The development of antiretroviral therapy has been a major challenge since the discovery of the human inununodeficiency virus (HIV). Early successes with nucleoside and non-nucleoside reverse transcriptase (RT) inhibitors, as well as the development of protease inhibitors have facilitated, in recent years, a highly active antiretroviral therapy (HAART), where a combination of drugs is simultaneously administered. In spite of significant improvements in the morbidity and mortality of HIV-infected patients, the rapid appearance of resistant HIV-variants, as well as adverse effects and high cost of contemporary drugs necessitate the continuous development of independent classes of anti-HIV agents. ... 

The design and application of bioisosteres in drug discovery has been and will continue to be an important approach to structural modification as medicinal chemists address the wide range of problems that are encountered in contemporary lead optimization initiatives. 

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