Psychotomimetic drugs

Psychotomimetic compounds are included here with the psychotropic drugs, as they are in the WHO classification, though their therapeutic usefulness is limited. They are so called because they induce, in normal subjects, changes in mood, perception or behaviour which mimic some of 

It is usual to classify as psychotomimetic, substances which produce predominantly psychotic effects in low concentrations. Many other drugs (cocaine, amphetamine and atropine, for instance) have psychotomimetic side effects or are effective psychotomimetics in relatively high doses. They are, therefore, not usually grouped with the psychotomimetic drugs, but since the criteria of psychotomimetic action are rather imprecise, differences of opinion do arise concerning the classification of some of the less active substances. The names and formulae of some of the compounds generally recognized as psychotomimetic are set out in Table 5.6. 

Mescaline is the active principle of the peyote cactus and its psychotomimetic properties were first recognized many centuries ago by primitive South American tribes who used peyote buttons in religious ceremonies. The priestly use of psychotomimetic compounds finds a ready explanation in the heightened sensory awareness and the sensation of looking upon 

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Psychotomimetic Drugs. Figure 2 Chemical structures of the dissociative anesthetics phencyclidine (PCP) and ketamine. Both are arylcycloalkylamine derivatives that are open channel blockers of the NMDA channel. 

Psychedelic Hallucinogen Psycho Energizers Psychomotor Stimulant Diugs Psychostimulants Psychotogenic Psychotomimetic Drugs PT... 

Shulgin AT Hallucinogens, in Burger s Medicinal Chemistry, 4th Edition, Part 3. Edited by Wolff ME. New York, Wiley, 1981, pp 1109-1137 Shulgin AT Psychotomimetic drugs structure-activity relationships, in Handbook of Psychopharmacology, Vol 11. Edited by Iversen LD, Iversen SD, Snyder SH. New York, Plenum, 1978, pp 243-336... 

Shulgin, A.T. Psychotomimetic drugs Structure-activity relationships. In Iversen, L.L. Iversen, S.D. and Snyder, S.H., eds. Handbook of Psychopharmacology. Vol. 11. New York Plenum, 1978. pp. 243-333. Shulgin, A.T., and Carter, MF. Centrally active phenethylamines. 

Freedman, D. X. (1963) Psychotomimetic drugs and brain biogenic amines. Am. J. Psychiatry. 

Bowers, M. B., Jr. (1972) Acute psychosis induced by psychotomimetic drugs I. Clinical findings. Arch. Gen. Psychiatry, 27 437-440. 

Freedman, D. X. (1969) Research strategies with psychotomimetic drugs. In Psychochemical Research in Man, edited by R. J. Mandell and M. P. Mandell, pp. 89-99. Academic Press, New York. 

Winters, W., and Wallach, M. (1970) Drug induced states of CNS excitation A theory of hallucinosis. In Psychotomimetic Drugs, edited by D. H. Efron, pp. 193-214. Raven Press, New York. 

Efron, D. H. (1970) Psychotomimetic Drugs. Raven Press, New York. 

Bradley, P. B., and Briggs, 1.(1974) Further studies on the mode of action of psychotomimetic drugs Antagonism of the excitatory action of 5-hydroxytryptamine by methylated derivatives of tryptamine. Br. J. Pharmacol., 50 345-354. 

Schultes, R.E. (1967). The place of ethnobotany in the ethnopharmacologic search for psychotomimetic drugs. In Ethnopharmacologic Search for Psychoactive Drugs Edited by D.H. Efron, et al., pp. 33-57. (Public Health Service Publication No. 1645). Washington, D.C. 

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