Publications time course

FIGURE 13.3 Time-course of publications L or Z and eye. The graph was produced by entering the search term lutein or zeaxanthin and eye, searching in all fields of the international biomedical research article database Pubmed for the years 1950-2008. The abstracts of the retrieved articles were checked to ensure that they were indeed relevant to the search term. The number of articles found was noted and plotted against the year of publication. 

Fig. 2. Individual plasma zl -tetrahydrocannabinol (THC) time course for six subjects following smoking of a single 3.55% THC cigarette. (Reproduced from the Journal of Analytical Toxicology by permission of Preston Publications, a division of Preston Industries Huestis et al. 1992b, Fig. Id therein)...

Fig. 5 Plasma concentration-time course of the antisense oligonucleotide trecovirsen in HIV-positive subjects, indicating a disproportional increase in systemic exposure after escalating doses. Trecovirsen was administered by 2-h intravenous administration to groups of 5 subjects (12 subjects for the 1.0 mg kg dose group). (Reproduced from [63] with permission of Sage Publications, Inc.)...

The time course of poisoning is dependent on the type of agent, the dose incorporated, and the route of exposure. Symptoms appeared minutes after inhalation of nerve agents and minutes to hours after incorporation of OP pesticides. Death can be observed (without treatment) within minutes after nerve agent inhalation and within hours to days after OP pesticide exposure. Description of the course of poisoning with OP and nerve agents can be found in many publications, either national or international, and it is mentioned in various different publications (B29, Ml, M2, LI5, and others). 

Figure 9.5 Illustration of genes expressed similarly during a time course of somatic cmbryogcnesis in one of the K-mcans cluster sets, set 6, of the microarray data. Adapted from Thibaud-Nissen, e( al The annotations matching clone IDs on the microarray sets represent the top Blastx hit in the public databases at a threshold of K -6. The putative function in cell metabolism is shown oth, other ox, oxidative strcss/dcfcnsc sig, signaling to, transcription u, unknown.

Figure 1 shows one representative time course of the impedance change of cell cultures. It is related to the value immediately after stimulation as a reference which is comparable to the unstimulated status before. The unstimulated culture which received cultivation medium without stimulant shows almost no signal change (-0.2%), whereas the stimulated cell culture has already an impedance increase of 26% after 1 h. This increase occurred in all stimulated cultures and is minimally smaller than stated in former publications with 28% to 55% measured after 1 to 4 h [3]. 

Sulfur mustard (SM) is unique among chemical warfare agents because of the large number of reports of its effects in man. The majority of these reports are of its effects after release on the battle field, and give a description of the types of effect and their time course from exposure to resolution of the injury. However, SM is also one of the few chemicals that have been the subject of tests on humans to determine how toxic they are in terms of the doses or dosages that produce toxic effects. Unlike reports of accidental or battlefield exposures, these trials were carried out in chambers under controlled, or at least carefully recorded, conditions, usually with analytical confirmation of chamber concentrations. Many of the reports of these trials, which were elassified at the time they were produced, have now been released into the public record and are available for scientific review. This chapter reviews those reports that are now available to the general public in addition to the work already published. Volunteer trials were carried out in the USA, UK, India and Australia. The reports of these trials that have been released to the public record are held by the Defense Technical Information Service... 

Was 1 prepared for the Nobel Prize 1 probably was, because over the years friends and colleagues had hinted that 1 had been nominated many times (of course, nobody really knows anything about the selection in advance). It is frequently said that the Nobel Prize represents the de facto end of the active research career of the recipients as they become public figures with little time left for scholarly work. However, I was determined that no prize or recognition would substantially change my life (see also Chapter 14). Furthermore, Judy, my life part-... 

Now consider the hypothetical problem of trying to teach the physics of space flight during the period in time between the formulation of Kepler s laws and the publication of Newton s laws. Such a course would introduce Kepler s laws to explain why all spacecraft proceed on elliptical orbits around a nearby heavenly body with the center of mass of that heavenly body in one of the focal points. It would further introduce a second principle to describe course corrections, and define the orbital jump to go from one ellipse to another. It would present a table for each type of known spacecraft with the bum time for its rockets to go from one tabulated course to another reachable tabulated course. Students completing this course could run mission control, but they would be confused about what is going on during the orbital jump and how it follows from Kepler s laws. 

Years ago, the author and Dr. Amos Banin from the Hebrew University of Jerusalem, Israel started to plan such a timely book to meet the current needs of the world s arid environments. Much research on biogeochemistry of trace elements in arid soils was done by the author and Dr. Banin during the period from 1992 to 1997 when the author was at the Hebrew University. Therefore, a majority of the chapters of this book were formed at that time. Of course, many materials and first-hand data are from the previous publications by the author and Dr. Banin s laboratory. Unfortunately, due to the health problems of Dr. Banin, he was unable to get this project finished. Thus this book is a product that resulted from the collaborative efforts and coauthoring between the author and Dr. Banin. 

There comes a time in any literary endeavour when one has to recognize that time has run its course, that a line has to be drawn in the sand, that one simply cannot continue to surf the Internet, that there is an ultimate limit to the recent publications that one can include in the final text. As the Thirteenth century Chinese scholar Tai T ung (The Six Scripts Principles of Chinese Writing) wrote Were I to await perfection, my book would never be finished. So, at the beginning of the veritable Twenty-first century, the real Third millenium, it is time to conclude, with all of the regrets which that implies. That perfection could ever be attained in a field which is undergoing such an explosive expansion and development at the present time is quite simply impossible. 

Mass spectrometry has meanwhile become an important part of academic education in analytical chemistry. It can be found in the curricula of most undergraduate as well as graduate courses in the field. The publication of this dedicated textbook is, therefore, a timely undertaking and the editors and authors are to be complimented for the effort to put the book together. 

In his Confessions d un chimiste ordinaire (1981), Jacques mused that this state of affairs exists partly because chemists rarely write about their discipline for the general public like their biologist and physicist colleagues. And chemists have contributed to the view of their metier as a descriptive, empirical science. Recalling a late-nineteenth-century course he attended at the Sorbonne, Lespieau remarked in 1913, "Four and a half hours was all the time devoted to generalities if one had doubled this time, it would not have been detrimental to the seventeenth property of chlorous anhydride. "5... 

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