Inositol hexakisphosphate

Hilton, J. M., Plomann, M., Ritter, B. etal. Phosphorylation of a synaptic vesicle-associated protein by an inositol hexakisphosphate-regulated protein kinase. J. Biol. Chem. 276 16341-16347,2001. 

Voglmaier, S.M. Bembenek, M.E. Kaplin, A.I. Dorman, G. Olszewski, J.D. Prestwich, G.D. Snyder, S.H. Purified inositol hexakisphosphate kinase is an ATP synthase diphosphoinositol pentakisphosphate as a high-energy phosphate donor. Proc. Natl. Acad. Sci. USA, 93, 4305-4310 (1996)... 

RID-2 <3> (<3>, RID-2, regulator of interferon-induced death, is identical to inositol hexakisphosphate kinase 2, IP6K2 [3]) [3] diphosphoinositol pentakisphosphate synthetase inositol hexakisphosphate kinase... 

S ATP -I- 1 D-myo-inositol hexakisphosphate <1> (<1>, enzyme is responsible for the biosynthesis of diphospho-myo-inositol pentakisphosphate. The enzyme also has a ATP synthase activity, implying that 5-diphos-pho-1 D-myo-inositol pentakisphosphate functions as high-energy phosphate donor [1]) (Reversibility r <1> [1]) [1]... 

Morrison, B.H. Bauer, J.A. Kalvakolanu, D.V. Lindner, D.J. Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of in-terferon-)S in ovarian carcinoma cells. J. Biol. Chem., 276, 24965-24970 (2001)... 

The most hydrophobic integral membrane proteins can be extracted into organic solvents such as mixtures of chloroform and methanol. One such proteolipid protein, the 23.5-kDa lipophilin, accounts for over half the protein of myelin.57 182 The purified protein from rat brain contains 66% of nonpolar amino acids and six molecules of covalently bound palmitic acid and other fatty acids per peptide chain in thioester linkage to cysteine side chains. This protein evidently has four transmembrane helical segments with the six fatty acid chains incorporated into the membrane bilayer. It also has cytoplasmic and extracellular loops, one of which binds inositol hexakisphosphate (Ins P-6). (Fig. 11-9).183 The myelin proteolipid is an essential component of the myelin sheath and defects in this protein are associated with some demyelinating diseases57 which are discussed in Chapter 30. 

Inositol hexakisphosphate (InsP6) 564 Inositol phosphates, scheme 565 Inositol polyphosphates... 

Phytase offers significant promise as a means to reduce phosphorus levels in animal waste by 30-35%, while also reducing the cost of phosphorus supplementation. The enzyme hydrolyzes phytate (myo-inositol hexakisphosphate), the primary storage form of phosphorus in plant seeds and pollen, in several steps into inositol and inorganic phosphorus, which is readily bioavailable to the farm animals. Phytases can also have non-specific phosphorus monoester activity. Addition of phytases to farm animals diets significantly enhances bioavailability of plant phosphorus for the animals while reducing phosphorus in the waste and simultaneously allowing a reduction of total phosphoms in the feed 500 units of phytase... 

Chaudhary, A., Mehrotra, B., and Prestwich, G. D. (1997). Rapid purification of reporter group-tagged inositol hexakisphosphate on ion-exchange membrane adsorbers. BioTech-niques 23, 427-430. 

Phytase phosphatase Aspergillus niger var. (1) myo-inositol- hexakisphosphate-3- phosphohydrolase (2) orthophosphoric-mono ester phosphohydrolase 3.1.3.8 3.1.3.2... 

Two isomers of inositol hexakisphosphate, myo- and. vey//o-isomers were investigated at different pH (Barientos and Murthy, 1996 Bauman et al., 1999). The two isomers differ in the orientation of the phosphate at one of six carbons, however, the impact of this on the proclivity toward ring flip to the sterically hindered form differs greatly. 

Shears, S.B., 2001, Assessing the omnipotence of inositol hexakisphosphate. Cell Signal. 13 151-158. 

Brearley, C.A., and Hanke, D.E., 1996a, Metabolic evidence for the order of addition of individual phosphate esters to the myo-inositol moiety of inositol hexakisphosphate in the duckweed Spirodelapolyrhiza L. Biochem. J. 314 227-233... 

Fujii, M., and York, J.D., 2004, A role for rat inositol polyphosphate kinases, rlpk2 and rlpkl, in inositol pentakisphosphate and inositol hexakisphosphate production in Rat-1 cells. J. Biol. 

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