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Proteins and hormones

Remmele et al. [3.55] studied with infrared spectroscopy the structure-hydration behavior of a 49.4 mg/mL lysozyme D20 solution with and without 10 % sucrose. The sample was cooled n in the measuring chamber to -100 °C and then connected to a freeze drying installation, after which the temperature of the sample was raised to +40 °C  [Pg.202]

Pikal [3.3] suggests also, that the mechanism of protection of proteins is different during freezing and drying. For the selection of CPAs, Pikal recommends to observe three points, which can be summarized  [Pg.202]

De Luca [3.5] recommends furthermore the addition of e. g. tertiary butylalcohol (TBA), to increase the transport of water vapor out of the product and to avoid collapse in sucrose-, [Pg.202]

Skrabanja et al. [3.6.] do not accept a combination of 12 different excipients e. g. for erythropoetin as the efficacy of each component cannot be proven. The mostly frequently used excipients are listed in five groups  [Pg.203]

Quick cooling is often advantageous, e. g. for recombinant DNA-proteins, in order to avoid crystallization of salts and to obtain the best possible, homogeneous cake. [Pg.203]

Freeze-Drying. SecondEdition. Georg Wilhelm Oeljen, Peter H aseley Copyright 2004 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim ISBN 978-3-527-30620-6 [Pg.295]

Hatley and Blair [3.69] presented mean Tg data for anhydrous carbohydrates (Table 3.1), which vary in the literature owing to measurement and interpretation differences. Small amounts of water may depress the data substantially. The physical stability of amorphous formulations below Tg is generally accepted, and a collapse can be avoided. This does not always apply to the chemical stability. If the temperature is reduced below T, the configurational entropy diminishes until it reaches zero. This T0 (also shown in Table 3.1) is called the zero mobility temperature at which the molecular motion stops. The authors define three areas of chemical reactions above Tg, chemical reactions are generally possible at T, reactions such as aggregation, which require substantial molecular motion, stop and between Tg and T0, reactions involv- [Pg.296]


Plasma consists of water, electrolytes, metabolites, nutrients, proteins, and hormones. The water and electrolyte composition of plasma is practically the same as that of ail extracellular fluids. Laboratory determinations of levels of Na, K+, Ca, CL, HC03, PaC02, and of blood pH are important in the management of many patients. [Pg.580]

Many enzymes are glycoproteins, as are many receptors, transport proteins, and hormones. They form an integral part of the membranes of mammalian cells. [Pg.214]

M17. Miedema, K., Boelhouwer, J., and Otten, J. W., Determinations of proteins and hormones in serum by an immunoassay using antigen-enzyme conjugates. Clin. Chim. Ada 40, 187-192 (1972). [Pg.103]

Microencapsulation has also been used medically for the encapsulation of live cells and vaccines. Biocompatibility can be improved by the encapsulation of artificial cells and biomolecules such as peptides, proteins, and hormones, which can prevent unwanted immunological reactions that would lead to inactivation or rejection. Microspheres are used for isolating materials until their activity is needed. The biotechnology industry employs microspheres to contain organisms and their recombinant products to aid in the isolation of these products. ... [Pg.2329]

Serum sodium is an example of a biological analyte that is affected by only a few sources of biological variation. However, the list of factors maybe rather long for other analytes, such as serum en2ymes, proteins, and hormone. [Pg.429]

In addition to offering a unique method for enzyme modification, we expect these studies to result in an improved method for the ncorpgratigg of stable radioisotopes into proteins and hormones ( Co, Co, Co). Further studies of the CD spectra of the models and azoproteins are expected to lead to a method for the determination of the extent and specificity of Co(III) modification of azoproteins and azohormones. [Pg.205]

Plasma coniains a variety of proteins with different functions. There are many characterized proteins whose function remains to be detennined. The biochemistry labtrratory rtmtinely measures total protein and albumin concentrations, usually in a serum specimen, and reports the globulin fraction as the difference between the first two results. Other proteins (e.g. immunoglobulins) arc measured as classes, and immunochemical methtxls arc available for measuring specific proteins and hormones. Enzymes are measured both by determining theiractivity and by immunochemical methods to assess their mass. [Pg.109]

Septicin antibacterial implant for the treatment of chronic bone infections have been developed [21-24]. The multidisciplinary concept of polymeric implants has expanded to include research on the chemistry and characterization of polymers, experimental and theoretical polymer degradation and drug release, toxicology and metabolism, and research in specific fields of applications such as cancer, proteins and hormones delivery, infectious diseases, and brain disorders. This chapter concentrates on the chemistry and characterization of polyanhydrides with a brief description on recent applications of polyanhydrides. [Pg.99]

Soy Protein and Hormone-sensitive Conditions Menopause, Cancer, and Bone Heaith... [Pg.756]

The mechanisms controlling expression of the symporter are often tissue-dependent and rely on a number of different proteins and hormones. [Pg.213]

Burger D, Dayer J M (2002). Cytokines, acute-phase proteins, and hormones IL-1 and TNF-alpha production in contact-mediated activation of monocytes by T lymphocytes. Annals NY Acad. Sci. 966 464-473. [Pg.1191]


See other pages where Proteins and hormones is mentioned: [Pg.242]    [Pg.454]    [Pg.38]    [Pg.201]    [Pg.203]    [Pg.205]    [Pg.207]    [Pg.209]    [Pg.211]    [Pg.269]    [Pg.92]    [Pg.201]    [Pg.203]    [Pg.205]    [Pg.207]    [Pg.209]    [Pg.211]    [Pg.295]    [Pg.297]    [Pg.299]    [Pg.301]    [Pg.303]    [Pg.305]    [Pg.307]    [Pg.309]    [Pg.311]    [Pg.263]    [Pg.170]    [Pg.822]    [Pg.822]    [Pg.2447]    [Pg.621]    [Pg.87]    [Pg.444]    [Pg.490]   
See also in sourсe #XX -- [ Pg.4 , Pg.295 ]




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