Protein conjugates Haemophilus influenzae type

Haemophilus influenzae type b Cultures of H. influenzae type b 1 Separation of capsular polysaccharide 2 Conjugation with a protein Estimation of capsular polysaccharide content ... 

Haemophilus influenzae type b (Hib) vaccines currently in use are conjugate products, consisting of either a polysaccharide or oligosaccharide of polyribosylribitol phosphate (PRP) covalently linked to a protein carrier. 

Each lyophilisate for one immunising dose of diphtheria, tetanus toxoids and pertussis with Haemophilus b conjugate vaccine contains Haemophilus influenzae type b polysaccharide conjugated to tetanus protein 10 meg, purified diphtheria toxoid 1 immunising dose, purified tetanus toxoid 1 immunising dose, Bordetella pertussis minimum of 4.1 lU. 

Haemophilus influenzae type b conjugate (Hib) Bacterial polysaccharid e conjugated to protein Intramuscular One dose (see Table 1-2 for childhood schedule) Not recommende d 1. For all childr en 2. Asple nia and... 

Weinberg GA, Granoff DM. Polysaccharide-protein conjugate vaccines for the prevention of Haemophilus influenzae type b disease. J Pediatr 1988 113(4) 621-31. 

Capsular polysaccharide of bacteria is one of the significant targets for development of vaccines [128]. For example, Haemophilus influenza type B (Hib) vaccine, made of a polysaccharide-protein conjugate, is now used worldwide as a highly effective therapy [129]. Verez-... 

Contains 5 meg 0.5 ml HBsAg and 7.5 meg Haemophilus influenzae type B purified capsular polysaccharide fragments conjugated to 125 meg Neisseria meningitidisouler membrane protein complex. 

Conjugates, which are vaccines that link a protein (toxoid) from an unrelated organism to the outer coat of the disease-causing microorganism. The result is a substance that is recognized by the immature immune system of young infants. Haemophilus influenzae type b is an example. 

Schneerson R, Barrera O, Sutton A, Robbins JB. Preparation, characterization, and immunogenicity of Haemophilus influenzae type b polysaccharide-protein conjugates. J Exp Med 1980 152 361-376. 

A further type of vaccine included in the subunit category is the capsular polysaccharide vaccines, for example, those against Haemophilus influenzae and meningococcal meningitis. In this case an extract of the polysaccharide outer capsule of the bacterium is used as a vaccine and is sometimes conjugated to protein to... 

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