Bendamustine hydrochloride

Biologically active substances have been linked to polyphosphates via ionic bonds between the substance and the polymer (Scheme 6.16). Troev and co-workers have reported the successful immobilization of drugs such as 2-phenylethylamine, cysteamine, and bendamustine hydrochloride, leading to enhanced stability and a lower cytotoxicity of the polymer-drug complexes than the pure analogs. 

Examples of substances that are prone to hydrolysis are acetylsalicylic acid, ampicillin, barbiturates, chloramphenicol, chlordiazepoxide, cocaine, corticosteroid phosphate or succinate esters, proteins, folinic acid, indomethacin, local anaesthetics, paracetamol (acetaminophen), pilocarpine, tropa alkaloids (atropine, scopolamine), xylomethazoline and the antimicrobial preservatives methyl and propyl parahydroxybenzoate. In the field of oncology, melphalan and bendamustine hydrochloride are highly susceptable to hydrolysis with a shelf life of 1.5 h for melphalan and 3.5 h for bendamustine at room temperature. 

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See also in sourсe #XX -- [ ]

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