Propionic 3- mercapto

Reducing the availability of GABA by blocking the synthesising enzyme GAD also promotes convulsions. This may be achieved by substrate competition (e.g. 3-mercapto propionic acid), irreversible inhibition (e.g. allylglycine) or reducing the action or availability of its co-factor pyridoxal phosphate (e.g. various hydrazides such as semi-carbazide). In fact pyridoxal phosphate deficiency has been shown to be the cause of convulsions in children. 

Semitelechelic HPMA polymers were synthesized by free radical polymerization of HPMA using 2,2 -azobis(isobutyronitrile) (AIBN) as the initiator and alkyl mercaptans as chain transfer agents. Alkyl mercaptans with different functional groups, namely, 2-mercaptoethylamine, 3-mercapto-propionic acid, 3-mercaptopropionic hydrazide, and methyl 3-mercapto-propionate, were used as the chain transfer agents ST HPMA polymers... 

To reach this target, bis-aminothiazoles, aromatic aldehydes, and 2-mercapto-propionic acid or 2-mercaptosuccinic acid were adsorbed on the neutral alumina support and were microwave-irradiated under solvent-free conditions (Scheme 56). The authors reported the high level of the reaction conversion, which gave the desired products 119 in excellent yields for a rather short time (up to 7 min). 

The iodinated precursor of FTP can be prepared in a one-step synthesis from 1,12-diiodododecane and 3-mercapto-propionic acid methyl ester. The... 

Ar-Acrylamidohexanoyl -lactosylamine 51 was telomerized (AIBN, MeOH) in the presence of either tcrt-butylmercaptan or methyl mercapto-propionate to provide families of discrete telomers 52 and 53 separable by size-exclusion chromatography (Scheme 9) [74,75]. Using 5.5 equivalents of t-BuSH per monomer gave monoadduct (27%), dimer (14%), trimer (1%), and higher telomers 52 (45%) in 87% yield. When methyl mercaptopropionate was used (0.43 eq), monoadduct 54 (26%), dimer (22%), trimer (12%), tetramer (7%), and hi er telomers 53 (n > 5,31 %) were obtained. 

Salts of basic species, such as TlU02(MeC02)(0H)2, and of mixed thiocyanato/carboxylato anions, such as Cs3(U02)3(MeC02)7(NCS)2, have been reported, but require further investigation. A variety of halo- and mercapto-propionates, U02(RC02)2, are also known. 

The use of extracellular lipases of microbial origin to catalyze the stereoselective hydrolysis of esters of 3-acylthio-2-methylpropionic acid in an aqueous system has been demonstrated to produce optically active 3-acylthio-2-methyl-propionic acid [41-43], The synthesis of the chiral side chain of captopril by the lipase-catalyzed enantioselective hydrolysis of the thioester bond of racemic 3-acetylthio-2-methylpropionic acid (15) to yield 5 -(-)-(15) has been demonstrated [44], Among various lipases evaluated, lipase from Rhizopus oryzae ATCC 24563 (heat-dried cells), BMS lipase (extracellular lipase derived from the fermentation of Pseudomonas sp. SC 13856), and lipase PS-30 from Pseudomonas cepacia in an organic solvent system (l,l,2-trichloro-l,2,2-tri-fluoroethane or toluene) catalyzed the hydrolysis of thioester bond of undesired enantiomer of racemic (15) to yield desired S-(-) (15), R-(+)-3-mercapto-2-methylpropionic acid (16) and acetic acid (17) (Fig. 8A). The reaction yield of... 

A synthesis of the functional core of the antibiotic leinamycin consisted of several steps, one of them being the preparation of an alkyl-substituted thietanone in moderate yield by cyclization of 2-mercapto propionic acid derivatives in isobutyl chloroformate and in the presence of triethylamine (Scheme 20) <2003T833, 2003PS1163>. 

Fig. 5. (Left) SEIRAS of NaHA and DNA on PAMAM dendrimer SAMs after adsorption for 30 min from aqueous solutions. Dendrimer SAMs were prepared by the amide bond formation of dendrimers with active ester groups of 3-mercapto-propionic acid (MPA) SAMs on CaF2 substrates. Infrared absorption spectra of NaHA, DNA, and PAMAM dendrimer are also included. (Right) Schematic illustration of the interactions between polyelectrolytes and dendrimer SAMs. Reprinted from Ref. [110].

Mercapto nicotinic acid nicosulfuron Mercapto propionic acid vamidothion... 

Nd, Tb, Tm (286. 287) Di(2-ethylhexyl) phosphoric acid [HDEHP] in cyclohexane none glycine 3-mercapto-propionic acid < = 2.53b oT 2.85 oT 2.35... 

L-Cysteine (Cys) (= (R)-2-Amino 3-mercapto-propionic acid (3-Mercapto-I -alanine)] (amino acid)... 

SYNS 7-a-ACETYLTHIO-3-OXO-17-a-PREGN-4-ENE-21,17-P-CARBOLACTONE 7-a-ACETYLTHIO-3-OXO-17-P-PREGN-4-ENE-21,17-P-CARBOLACTONE ALDACTIDE ALDACTONE ALDACTONE A 3-(3-KETO-7-a-ACETYLTHIO-17-P-HYDROXY-4-ANDROSTEN-17-a-YL)PROPIONIC ACID LACTONE OSIREN OSYROL 3 -(3-OXO-7-a-ACETYL-THIO-17-P-HYDROXYANDROST-4-EN-17-P-YL)PRO-PIONIC ACID LACTONE 17-a-PREGN-4-ENE-21-CARBOXYLIC ACID, 1 -HYDROXY-7-a-MERCAPTO-3-OXO-a-LACTONE SC 9420 SC 15983 SPIRESIS SPIRIDON SPIROCTANIE SPIRO(17H-... 

SYNS 2,2-DIBUTYLDIHYDRO-6H-l,3,2-OXATHIASTANNIN-6-ONE 2,2-DIBUTYL-l-OXA-2-STANNA-3-THIACYCLOHEXAN-6-ONE DIBUTYLTIN-0,S-MERCAPTOPROPIONATE DIBUTYLTIN-S,0-3-MERCAPTOPROPIONATE DIBUTYLTIN-S,0-p-MERCAPTOPROPIONATE DIBUTYL(3-MERCAPTO-PROPIONATO(2-))TIN MERCAPTO-PROPIONIC ACID, DIBUTYLTIN SALT... 

Testosterone. A 4-Chloro 17-acetate (S-114), 4-bromo (S-8), 4-methyl (S-11), 4-chloro 11/3-hydroxy 17-acetate (S-7), 4-fluoro 17-acetate (S-9), 4-hydroxy 17-acetate (S-10), la-methyl 4-chloro 17-acetate (S-79), 4-chloro 17-propionate (S-6), 4-hydroxy 17a-methyl (S-16), 4-chloro Ha-methyl (S-17), 4-mercapto 17a-methyl (S-49), 4-methylthio 17a-methyl (S-50), 4-ethylthio 17a-methyl (S-51), 4-acetylthio 17a-methyl (S-52), and 4-chloro 11/3-hydroxy 17a-methyl (S-102) substitutions all decrease the androgenic property. However, the anabolic potency is only slightly decreased and in a few cases increased, such as S-114, S-11, S-16, S-6. Substitution at the 4-position by bulky substituents i.e., 4-ethyl (S-13) and 4-allyl (S-14), abolishes both activities. 

The mercapto-propionic add derivative (II) of molinate, conjugated to hemocyanin, provided the immunizing antigen for antibody production ). The only significant crossreactivity toward this antibody was exhibited by the mercapto-propionic add derivative and some other dosely related derivatives of molinate (Table III). Of these, only the sulfone is a metabolite of molinate in the environment. Thiobencarb, another thiolcarbamate rice herbidde, and still other thiolcarbamate showed essentially no cross-reactivity (Table El). 

METHYLTHIO BUTYRATE METHYL 3-METHYLTHIO PROPIONATE 4-METHOXY- METHYL BUTANE-2-THI0L 8-MERCAPTO MENTHAN-3-0NE... 

CIC The basic Muscat note is produced from linalool, balanced with further terpene alcohols, geraniol and linalool oxides. The catty odour of the concord grape is based on methyl anthranilate, combined with ethyl-3-mercapto propionate, benzaldehyde adds the touch of a seedy character. 

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