Methyl 3-mercaptopropionate

Michael-Type Additions. Michael additions are generally used to prepare methyl 3-mercaptopropionate (eq. 10) and mercaptopropionitrile (eq. 11) by the reaction of methyl acrylate or acrylonitrile and hydrogen sulfide using a basic catalyst. This reaction proceeds as shown ... 

Figure 1 The effect of concentration ratio of mercaptans ( , 2-mercaptoethylamine , methyl 3-mercaptopropionate , 3-mercaptopropionic acid , 3-mercaptopropionic hydrazide) to HPMA on the weight average molecular weight (SEC) of ST HPMA polymers (data from Reference [20]). 

Compounds described as the 15 -carboxymethyl derivatives (32) of oestrone and oestradiol have been described as haptens, without any evidence as to their configurations at C-15, or their homogeneity. The method of synthesis (via Michael addition of malonic ester to the 15-en-17-one) normally gives 15/8-substituted compounds. Some 15/8-carboxyethylmercaptoandrostane derivatives (33), obtained by addition of methyl 3-mercaptopropionate to androst-15-en-... 

Ohuchida, Hamanaka, and Hayashi (20) have reported a synthesis of the dithia-analogue 21 of tromboxane A. In one of the key steps, the stereoelectroni-cally controlled axial conjugate addition of methyl 3-mercaptopropionate to 68 was realized with stereoselectivity by using diisopropyl ethyl amine (0.2 equiv) in DMF. The product obtained 69, was then converted into 70 which was further transformed into the desired dithio derivative 21 [(a) t-BuoV, HMPA, 25°C (b) NaOCH3, CH3OH (c) NaOH 0.2 N, THF]. 

EINECS 220-912-4 HSDB 5905 3-Mercaptopropionic acid methyl ester Methyl mercaptopropionate Methyl 3-mercaptopropionate NSC 137814 Propanoic acid, 3-mercapto-, methyl ester. Liquid bp14 = 54-55° d = 1.085. 

The polymers were synthesised from boc-protected amine monomers and alkyl or benzyl methacrylate monomers. The polymerisation was performed by applying AIBN, as a radical initiator, and methyl 3-mercaptopropionate, as a chain transfer agent, in acetonitrile. The treatment of boc-protected polymers with TFA produced amphiphilic random copolymers with cationic ammoninm groups in the side chains. 

Mercaptopropionic acid methyl ester. See Methyl 3-mercaptopropionate... 

M ethyl mercapto) propionaldehyde. See 3-Methylthiopropionaldehyde Methyl 3-mercaptopropionate CAS 2935-90-2... 

Scheme 30.7 Thiol-ene click modification of 1,2-polybutadiene with (1) methyl 3-mercaptopropionate, (2) N-Boc-cysteine, (3) 2,3,4,6-tetra-O-acetyl-l-thio- -glucopyranose, and (4) thiocholesterol. A...

The novel partially crystalline polymer (3) with munber-average molecular weight (M ) of up to 5700 was prepared imder various conditions by catalyzed self-condensation of 3-hydroxypropyl methoxycarbonylethyl sulfide (4) or 3-hydrox5 ropyl carboxyethyl sulfide (5) (22). The degree of crystallinity, melting temperature (Tm and temperature of initial decomposition (Ta) were 36-46%, 37-47°C, —61 to —70°C, and 164-260°C, respectively. The monomers (4) and (5) were prepared by an addition of methyl 3-mercaptopropionate and 3-mercaptopropionic acid with allyl alcohol [107-18-6] catalyzed by AIBN [2,2 -azobis(2-methylpropionitrile), azobisisobutyronitrile, azodiisobutyro-dinitrile, 2,2 -azobis(2-methylpropanenitrile), a,a -azodiisobutyronitrile, 2,2 -azo-bis(isobut5T onitrile), 2,2 -dicyano-2,2 -azopropane, Porofor-57, 2,2 -dimethyl-2,2 -azodipropionitrile, 2,2(-azobis(2-methylpropionitrile))] [78-67-1]. 

The formation of mercaptofurfuryl [9] and methyl-3-mercaptopropionate [10] complexes of La, Ce, Pr and Sm(III) have been established on the conductometric titration of alcohol solutions of Ln(N03)3. The complexes were not isolated from the solutions. 

A soln. of methyl 5,5-dimethyl-2-phenyl-2-thiazoline-4-carboxylate in dimethoxy-cthane added at -15° to a stirred soln. of K- er butoxide in the same solvent, after 10 min. methyl iodide in the above solvent added during 15 min., and stirring continued 2 hrs. methyl N-(l-methoxycarbonyl-2-methylprop-l-enyl)thio-benzimidate (Y 75%) mixed with methyl 3-mercaptopropionate, and heated 20 hrs. at 120° with evolution of methanethiol -> 2-methoxycarbonylethyl N-(l-methoxycarbonyl-2-methylprop-l-enyl)thiobenzimidate (Y 75%). - Direct prepn. was not successful. M. D. Bachi and M. Rothfield, Soc. Perkin I 7972, 2326. 

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