Propionic acid ethyl ester

Phenyl(3-a -"ethylpropionate ), 4-carboxamide] -tetrazanetll. Note a-ethylpropionate (or more correctly, in the opinion of the editor, a-ethylpropionatyl) is the proper name for the radical —CH(CH3).CCfe-C2H5, derived from a-propionic acid ethyl ester. (C6H5).N N.N[CH(CH3).C02.C2H5].NH(C0.NH2), mw 279.34, N 25.08%, crysts from aq ale, mp (melts with expln ca 125°)... 

The reaction of potassium 3-amino-4-oxo-3,4-dihydroquinazoline-2-thiolate 62 with a-bromophenylacetic acid 63 resulted in the formation of (3-amino-4-oxo-3,4-dihydroquinazolin-2-ylsulfanyl)-phenyl-acetic acid methyl ester 64 which on alkali treatment and subsequent acidification resulted in the synthesis of 2-phenyl- 1-thia-4,4a,9-triaza-anthracene-3,10-dione 65 <1999JCR(S)86>. Similarly, the reaction of potassium 3-amino-5,6-dimethyl-4-oxo-3,4,4a,7a-tetrahydrothieno[2,3- pyrimidine-2-thiolate 66 with a-bromo-ester 67 resulted in the formation of 2-(3-amino-5,6-dimethyl-4-oxo-3,4,4a,7a-tetrahydrothieno[2,3- / pyrimidin-2-ylsulfanyl)-propionic acid ethyl ester 68. Subsequent treatment with alkali followed by acidification resulted in the formation of 2,3,7-trimethyl-3a,9a-dihydro-l,8-dithia-4a,5,9-triazacyclopenta[ ]naphthalene-4,6-dione 69 <2000JHC1161>... 

Beccalli et al. reported a new synthesis of staurosporinone (293) from 3-cyano-3-(lH-indol-3-yl)-2-oxo propionic acid ethyl ester (1464) (790). The reaction of 1464 with ethyl chlorocarbonate and triethylamine afforded the compound 1465, which, on treatment with dimethylamine, led to the corresponding hydroxy derivative 1466. The triflate 1467 was prepared from 1466 by reaction with trifluoromethanesulfonic anhydride (Tf20) in the presence of ethyldiisopropylamine. The palladium(O)-catalyzed cross-coupling of the triflate 1467 with the 3-(tributylstannyl)indole 1468 afforded the vinylindole 1469 in 89% yield. Deprotection of both nitrogen atoms with sodium ethoxide in ethanol to 1470, followed by photocyclization in the presence of iodine as the oxidizing agent provided the indolocarbazole 1471. Finally, reductive cyclization of 1471 with sodium borohydride-cobaltous chloride led to staurosporinone (293) in 40% yield (790) (Scheme 5.248). 

Sodium 2-Bromo-2-methyl-propionic acid ethyl ester... 

Dicyano propionic acid ethyl ester fipronil Dicycloheptadiene aldrin... 

SYNS ETHYL ISOBUTANOATE ETHYLISOBUTY-RATE POT ETHYL-2-METHYLPROPANOATE ETHYL-2-.METHYLPROPIONATE FEMA No. 2428 ISOBUTYRIC ACID, ETHYL ESTER 2-METHYL-PROPIONIC ACID, ETHYL ESTER... 

SYNS FEMA No. 2456 PROPIONATE d ETHYLE (FRENCH) PROPIONIC ACID, ETHYL ESTER PROPIONIC ETHER... 

Ether, dimethyl 8.8 Propionic acid, ethyl ester 8.4... 

ETHOXY PROPIONIC ACID, ETHYL ESTER (763-69-9) Forms explosive mixture with air above 138°F/59°C. Incompatible with strong acids, nitrates, oxidizers. 

FIGURE 16.10 Preparation of the chiral C-13 paclitaxel side-chain synthon. (A) Enantio-selective microbial reduction of 2-keto-3-(Al-benzoylamino)-3-phenyl propionic acid ethyl ester 36. (B) Enantioselective enzymatic hydrolysis of cw-3-(acetyloxy)-4-phenyl-2-azetid-inone 38. 

To a flame-dried, round-bottomed flask was added 13.0 mg triazolium salt (0.031 mmol) and 2 mL toluene. To this solution was added 61 /uL 0.5 M KHMDS solution (0.031 nomol) via syringe, and the solution was stirred at ambient temperature for 5 min. Toluene and HMDS were removed in vacuo by placement under high vacuum for 1 h. Then 3 mL toluene was added, followed by a solution of 38.0 mg substrate in 2 mL toluene, and the resulting solution was allowed to stir at ambient temperature for 24 h. The reaction was quenched with 2 mL 15% AcOH/toluene and concentrated. The residue was purified by flash column chromatography using mixture of hexane and EtOAc (6 1) as the eluent to afford 35.7 mg (2/ ,3 5 )-(4-oxo-chroman-3-yl)-propionic acid ethyl ester as a white solid, in a yield of 94%. The product was tested to be pure enough with 95% e.e. and 30 1 dr, Rf = 0.7 (hexane/EtOAc, 1 1). 

Synonyms Ethyl propanoate Propanoic acid ethyl ester Propionic acid, ethyl ester Propionic ether Classification Carboxylic acid ester Definition Ester of propionic acid and ethyl alcohol Empirical CsHmOj Formula CH3CH2COOC2H5... 

Propionic acid, ethyl ester. See Ethyl propionate Propionic acid, 2-hydroxy-. See Lactic acid Propionic acid, 2-methyl-. See Isobutyric acid... 

Scheme 2.8. Reagents and conditions (i) DIEA, 3-ammo-propionic acid ethyl ester, DMF, 25° C.

Patel RN, Banerjee A, Howell JM, McNamee CG, Brzozowski D, Nanduri V, Thottathil JK, Szarka LJ (1995) Stereoselective Microbial Reduction of 2-Keto-3-(N-benzoylamino)-3-phenyl Propionic Acid Ethyl Ester Synthesis of Taxol Side-Chain Synthon. Ann NY Acad Sci 750 166... 

Ethyl propionate (propionic acid ethyl ester) n. Colorless liquid, fruity odor. Medium boiling solvent for nitrocellulose. Properties bp, 98°C Sp gr, 0.912/0°C flip, 12°C (43.6°F) vp, 43mmHg/30°C. 

Male rats treated with either clofibrate [2-(p-chloro-phenoxy)-2-methyl-propionic acid ethyl ester] or nafenopin [2-methyl-2-(p-l,2,3,4-tetrahydro-l-naph-thyl)phenoxypropionic acid], two peroxisome proliferating compounds with potent hypoHpidemic properties, showed identical structural changes in their lungs (Fringes and Reith 1988). 

C5H10O2 105-37-3 Propionic acid ethyl ester see Ethyl propanoate... 

Preparation of (5)-3,3,3-trifluoro-2-hydroxy-2-(5-methyl-3-indolyl)-propionic acid ethyl ester (105, Ri = Me) from 102 (Ri = Me), and 96 via cinchonidine alkaloid catalyst 102 ... 

Ethylene reacts with carbon monoxide and water in the presence of nickel carbonyl to give propionic acid in high yield. If care is taken to maintain a high concentration of propionic acid in the reaction mixture and the temperature, which is normally 300 in the propionic acid synthesis, is decreased to 240 °C propionic acid anhydride is formed in high yield in the presence of Ni(CO)4. Propionic acid ethyl ester is the main product in the reaction of ethylene, carbon monoxide and water (low water concentration must be applied) with cobalt carbonyls instead of Ni(CO)4. The conversion of ethylene with carbon monoxide in dilute alkaline medium with the aid of potassium nickel cyanide gives propionyl propionic acid [403-405]. At higher temperatures and without pH correction in the same reaction mainly polyketones with the sequences -(CHg-CHg-CO)- are formed. If the reaction is carried out in absence of water or alcohols and in presence of palladium iodide as catalyst, a mixture of hexenolide isomers is the main product. Colorless polyketones of the same structure are obtained if an excess of ethylene is treated with carbon monoxide in the presence of complex palladium salts as catalysts in an alcoholic hydrogen halide solution at 100 °C and 700 atm [406]. 

CgH8Br202 2,3-dibromo-propionic acid ethyl ester 3674-13-3... 

C5H9CIO 2 ( )-2-chloro-propionic acid ethyl ester 105309-19-1 ... 

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