Propiomazine hydrochloride

Infra-red Spectrum. Principal peaks at wavenumbers 754, 1653, 1221,1186,1575,1316 (propiomazine hydrochloride, KBr disk). (See below)... 

ANTIBACTERICAL, ANTIFUNGAL, antifungicide and ANTIVIRAL properties. It can be used as a vapour and is rather toxic, propiomazine [ban, inn, usan] (propiomazine hydrochloride [usan] propiomazine maleate Wy 1359 Propavan ) is a phenothiazine with HISTAMINE H -RECEPTOR ANTAGONIST properties, but is used as a SEDATIVE, a HYPNOTIC and in preoperative medication, propiomazine hydrochloride propiomazine. propiomazine maleate propiomazine. propiram [ban, inn] (propiram fumarate [usan] Bay 4503) is one of the phenylpiperidine series, an opioid RECEPTOR AGONIST with OPIOID ANALGESIC activity. 

Propiomazine hydrochloride is designated by the following chemical names ll0-(2-dimethylaminopropyl)-2-propionylphenothiazine hydrochloride, and propionyl-promethazine hydrochloride , In the subject indices of Chemical Abstracts, the compound is listed under the heading l-[10-l2-(dimethylamino) propyl] phenothiazin-... 

Propiomazine hydrochloride is a yellow, practically odorless powder. ... 

The infrared spectrum of propiomazine hydrochloride (N.F. Reference Standard material), presented in Figure 1, has been run in a KBr pellet. The following absorption band assignments have been made. ... 

Figure 1. I.R. Spectrum of Propiomazine Hydrochloride (N.F. Reference Standard Material) - 1% KBr Instrument Perkin Elmer Model 21...

Tompsett reportedA max. at 2h2 mu and 273 mu for propiomazine hydrochloride in IN hydrochloric acid.5 Propiomazine hydrochloride (N.F. Reference Standard material) when scanned between 350 mu and 220 mu exhU.ited Amax. at 2 2 mu (fi-67.5) and 273 mu (e-[t5.2).° This spectrum is shown in Figure 3 ... 

The mass spectrum of propiomazine hydrochloride (N.F. Peference Standard material) was obtained by direct insertion of the sample into an MS-902 double focusing mass spectrometer. The ion source temperature was 200°C. and the ionizing electron beam energy was 60 eV. The high resolution data was compiled and tabulated with the aid of an on-line PDP-8 Digital Computer. 

The differential thermal analysis (DTA) curve of propiomazine hydrochloride (N.F. Reference Standard material) run from room temperature to the melting point exhibits no endotherms or exotherms other than an endotherm at 199 - 203 C. associated with the melt. Since the compound melts with decomposition, this endotherm is not well defined. The DTA curve was run on a Dupont 900 DTA using a micro cell and a heating rate of 5°C./min. 

The following approximate solubility data have been determined for propiomazine hydrochloride at room temperature... 

Two basic synthetic routes have been reported for the preparation of propiomazine hydrochloride. Farbenfabriken Bayer prepared propiomazine by reacting 2-dimethyland.no-propyl chloride with 2-propionylphenothiazine in the presence of sodium amide as the condensing agent, and subsequently converting the base form to the hydrochloride (See Figure 6). 

The ultraviolet absorption maximum of propioma-zine hydrochloride at about 2li0 mu in aqueous solutions has been utilized for assay purposes. Determination of the absorptivity value is useful for assay of raw material and for formulations after the propiomazine has been isolated. Propiomazine hydrochloride could possibly be separated from interfering formulation components by an extraction of the base form with organic solvents from an alkaline aqueous solution. 

Modifications of the palladium-phenothiazine derivative complex procedure of Ryan ° have been applied to the quantitative analysis of propiomazine hydrochloride successfully. j The colorimetric procedure is based on the reaction of palladium with propiomazine in an aqueous solution buffered at about pH 3 to form a colored complex which is spectrophotometrically measured at U65 m/u. Since this complex formation is based on an electron transfer from the sulfur moiety to the palladium ions, the procedure provides a method to assay propiomazine in the presence of its corresponding sulfoxide oxidative decomposition product. 

Propiomazine hydrochloride exhibits an anodic wave at +0.8v in acidic aqueous solution at a concentration range of 10 - to 10 5k using a stationary platinum electrode vs. a calomel reference electrode, suitable for a quantitative assay O. The wave corresponds to the oxidation of the stilfur in the phenothiazine nucleus to the sulfoxide l. 

The non-aqueous potentiometric titration of amine hydrochloride salts, introduced by Pifer-Wollish and used in the assay of various phenothiazine derivatives can be applied to the determination of propiomazine hydrochloride. The procedure involves initial reaction of the amine hydrochloride group with mercuric acetate in an acetic acid medium. The halide is tied up as undissociated HgClg and the acetate ion liberated can be titrated as a base with perchloric acid, hercuric acetate is essentially undissociated in acetic acid and the excess, therefore, does not interfere. 

Chromatographic methods can be used qualitatively for identification and quantitatively for determination of purity and stability of propiomazine hydrochloride. 

The various eluant and adsorbent systems used for thin layer chromatography of propiomazine hydrochloride are given in Table III. The visualization techniques used for the detection of propiomazine are also included in Table III. 

Many paper chromatographic methods have been reported in the literature to permit the isolation and detection of propiomazine hydrochloride. A summary of the available data is recorded in Table IV. 

Propiomazine hydrochloride has been chromatographed at an operating temperature of 22 "c. on a 2, % SE-30 Chromosorb W column and a 3 XE-60 silicone nitrile polymer on Chromosorb W column. Employing a 3% 5 E-30 Diatoport S column operated at a temperature of PliO C., it is possible to separate propiomazine hydrochloride fxom its degradation product, 2-propjpnyl phenothiazine... 

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