Product and formulation

Wilson MJ, Grewal PS. Biology, production and formulation of slug-parasitic nematodes. In Grewal PS, Ehlers R-U, Shapiro-Ilan DI, editors. Nematodes as biocontrol agents. Wallingford, UK CAB International 2005. pp. 421-429. 

Munir, A. 2005, Pesticide product and formulation design, MSc-thesis, CAPEC, Department of Chemical Engineering, DTU, Lyngby, Denmark. 

For the dissolution test to be used as an effective drug product characterization and quality control tool, the method must be developed with the various end uses in mind. In some cases, the method used in the early phase of product and formulation development could be different from the final test procedure utilized for control of the product quality. Methods used for formulation screening or BA and/or bioequivalency evaluations may simply be impractical for a quality control environment. It is essential that with the accumulation of experience, the early method be critically re-evaluated and potentially simplified, giving preference to compendial apparatus and media. Hence, the final dissolution method submitted for product registration may not necessarily closely imitate the in vivo environment but should still test the key performance indicators of the formulation. 

Drug development then addresses toxicological, production, and formulation concerns before clinical trials can begin. 

H Buser, K Grolimund. Direct determination of A -phenyl urea derivatives in herbicide technical products and formulations, using gas-liquid chromatograpy. J Assoc Off Anal Chem 57 1294-1299, 1974. 

Verifying that manufacturing equipment and product formulation are finalized (e.g., as specified in a development transfer report)—This is necessary since cleaning methods are product- and formulation-specific and will change if the formulation or equipment is changed. 

HELCOM Recommendation 23.10.2002 Reduction of discharges and emissions from production and formulation of pesticides. 56-60. Helsinki (Finland) Adopted March 6, having regard to Article 20, Paragraph 1 b) of the Helsinki Convention. Annex 12. 

An overview is presented of antifoam chemistry from Degussa and its application to the production and formulation of organo-modified siloxane anti-foaming agents for polyvinyl chloride. 7 refs. 

Type of product and formulation, e.g. live or inactivated vaccine, vector vaccine, type of vector, liquid or lyophilized product, adjuvant, special formulations. 

Improve transparency by disclosing all products and formulations stating the countries in which they are manufactured, formulated, stored and sold ... 

Purchase of inappropriate products and formulations Poor quality of pesticides and lack of analytical facilities Inappropriate packaging size and labelling Excessive donations and poor co-ordination among aid agencies Change of national policy... 

The viscous, spreadable compounds which have to be supplemented by a catalyst and - depending on product and formulation - a crosslinking agent, crosslink quickly when heated to form insoluble coatings resistant to washing and cleaning. 

I) powder production and formulation and (II) powder inhaler devices. 

The drug substance, drug product, and formulation excipients ... 

Process aid (antifoam and deaeration agent in, e.g., paper and textile industry, in agrochemicals, dispersion production and formulation, adhesives)... 

The nature of the crystalline form of a drug substance may affect its stability in the solid state, its solution properties and its absorption. It is with this last topic that we start, to consider later other properties of the solid state important in production and formulation. Recently, nanoparticles have been produced to improve the absorption of poorly soluble drugs. 

Secondary reactions may occur between the primary gaseous products and formulation of mechanisms requires consideration of the possible participation of processes such as the water-gas equilibrium ... 

Furda, I. et al., Decomposition products of L-aspartyl-L-phenylalanine methyl ester in various food products and formulations, J. Agric. Food Chem., 23, 340, 1975. 

Polyurethane products and formulated systems are used in rigid foams, flexible foams, adhesives, sealants, coatings and elastomers, as well as in many other applications. Propene glycols are used in a wide variety of end-use and industrial applications, from unsaturated polyester resins, cosmetics and household detergents, to paints and automotive brake fluids. Propene glycol ethers are commonly... 

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