Prochlorperazine maleate

Prochlorperazine Maleate. 2-Chloro-10-[3-(4-methyl-l-piperazinyl)-propyl]-10 H-phenothiazine maleate [84-02-6] (Compazine) (22) is a white or pale yellow crystalline powder. It is almost completely odorless, its saturated solution is acidic to litmus, it is practically insoluble in water and ethanol, and it is slightly soluble in warm chloroform. It may be made by the synthesis described in Reference 18. Prochlorperazine maleate [84-02-6] is an effective antiemetic and tranquilizing agent. It is not particularly effective for motion sickness. Adverse reactions that may occur include extrapyramidal reactions, motor resdessness, dystonias, tardive dyskinesia, and contact dermatitis. Prochlorperazine is also a significant phenothiazine antipsychotic. 

Dose. Usually 15 to 30 mg of prochlorperazine maleate daily, as an anti-emetic 50 to 100 mg daily for the treatment of psychoses. 

Oxytetracycline Hydrochloride 538.7 Sodium Fusidate 606.1 Prochlorperazine Maleate... 

Examples of marketed mucoadhesive formulations are Attach buccal tablets (triamcinolone acetonide), Susadrin sublingual tablets (nitroglycerin Forest Laboratories, NY), and Buccastem buccal tablets (prochlorperazine maleate Reckitt and Colman, England). 

Prochlorperazine Maleate (25) Compazine SmithKline Beecham Phenothiazine (piperazine) 15 15-150 PO, IM... 

Prochlorperazine maleate buccal tablets are licensed for the non-prescription treatment of nausea and vomiting associated with migraine. 

The vast majority of salt forms are developed to enhance the aqueous solubihty of drug substances. In some cases, a salt may be preferred with reduced solubihty for use in suspension formulations where solubihty as low as possible is optimum to prevent Ostwald ripening, for taste masking or to prepare a sustained release product. Chlorpromazine is marketed as a tablet and syrup using the hydrochloride salt but the insoluble embonate salt is used in suspension formulations to extend the duration of achon and minimize taste problems. Occasionahy the selection of a salt with only modest aqueous solubihty may be more suitable for use in tablet products prepared by wet granulation. For example, prochlorperazine maleate is used in Stemehl tablets rather than the highly soluble mesylate salt. 

PROCHLORPERAZINE MALEATE (Chlorazine, Compazine, Compazine Spansule)... 

Potassium Gluconate Prochlorperazine Ethane-disulphonate, U.S.P. Prochlorperazine Maleate, U.S.P. 

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