Mucoadhesive Formulations

With the aim of maintaining and restoring the physiological acidic conditions that can be compromised for example in postmenopausal age, with irritation of the mucosa, itching, and unpleasant smell, a mucoadhesive formulation capable of sustained release of lactic acid, based on a chitosan lactate gel has also been proposed [59,60]. 

Liposome-Based Mucoadhesive Formulations for Oral Delivery of Macromolecules... 

Another type of novel mucoadhesive formulations was suggested to be submicron emulsions (o/w), bearing droplets coated with Carbopol 940. These formulations... 

Examples of marketed mucoadhesive formulations are Attach buccal tablets (triamcinolone acetonide), Susadrin sublingual tablets (nitroglycerin Forest Laboratories, NY), and Buccastem buccal tablets (prochlorperazine maleate Reckitt and Colman, England). 

To increase the residence times of drugs in the conducting airways served by the mucociliary escalator, mucoadhesive formulations were investigated [134]. This approach can be effective, but safety consequences of slowing down this natural clearance mechanism will need to be investigated. 

The above mentioned effects suggest the possible use of S. sclarea oil in the stomatological field to treat infective conditions which are often accompanied by inflammation. Since anti-inflammatory and analgesic effects require some drug absorption, some research [56-57] has been done recently to evaluate the capacity of the essential oil components to permeate the oral mucous in various mucoadhesive formulations of the oil (microemulsions, hydrogels and gelled microemulsions), useful in local treatments of stomatological ailments. The permeation properties of the... 

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