Process near-infrared spectroscopy

Workman J Jr. A review of process near infrared spectroscopy 1980-1994. J Near Infrared Spectrosc 1993 1 221-245. 

Characterization. In many cases, ftir is a timely and cost-effective method to identify and quantify certain functionaHties in a resin molecule. Based on developed correlations, ftir is routinely used as an efficient method for the analysis of resin aromaticity, olefinic content, and other key functional properties. Near infrared spectroscopy is also quickly becoming a useful tool for on-line process and property control. 

The phase composition of glycine crystal forms during the drying step of a wet granulation process has been studied, and a model developed for the phase conversion reactions [88], X-ray powder diffraction was used for qualitative analysis, and near-infrared spectroscopy for quantitative analysis. It was shown that when glycine was wet granulated with microcrystalline cellulose, the more rapidly the granulation... 

Near-infrared spectroscopy is quickly becoming a preferred technique for the quantitative identification of an active component within a formulated tablet. In addition, the same spectroscopic measurement can be used to determine water content since the combination band of water displays a fairly large absorption band in the near-IR. In one such study [41] the concentration of ceftazidime pentahydrate and water content in physical mixtures has been determined. Due to the ease of sample preparation, near-IR spectra were collected on 20 samples, and subsequent calibration curves were constructed for active ingredient and water content. An interesting aspect of this study was the determination that the calibration samples must be representative of the production process. When calibration curves were constructed from laboratory samples only, significant prediction errors were noted. When, however, calibration curves were constructed from laboratory and production samples, realistic prediction values were determined ( 5%). 

Near-infrared Spectroscopy for Process Analytical Technology Theory, Technology and Implementation... 

P.J. Brimmer, F.A. DeThomas and J.W. Hall, Method development and implementation of near-infrared spectroscopy in industrial manufacturing processes, in Near-Infrared Technology in the Agricultural and Food Industries, P. Williams and K. Norris (eds), 2nd edn, American Association of Cereal Chemists, Inc., St. Paul, MN, 2001. 

D.S. Goldman, Near-Infrared spectroscopy in process analysis, in Encyclopedia of Analytical Chemistry, J.W. Peterson (ed.), vol 9, Process Instrumental Methods, John Wiley Sons, New York, 2000. 

K.A. Bakeev, Near infrared spectroscopy as a process analytical tool, part 1 laboratory applications. Spectroscopy, 18(11), 32-35 (2003). 

PA. Hailey, P. Doherty, P. Tapsell, P.T. Oliver and PK. Aldridge, Automated system for the on-line monitoring of powder blending processes using near-infrared spectroscopy, part 1. system development and control, J. Pharm. Biomed. Anal, 14, 551-559 (1996). 

M. Warman, Using near infrared spectroscopy to unlock the pharmaceutical blending process. Am Pharm. Rev., 7(2), 54-57 (2004). 

Z.H. Ge, B. Buchanan, J. Timmermans, D. De Tora, D. Elhson and J. Wyvratt, On-hne monitoring of the distillates of a solvent switch process hy near-infrared spectroscopy. Process Contr. Qual., 11(4), 277-287 (1999). 

M. Blanco and D. Serrano, On-hne monitoring and quantihcation of a process reaction by near-infrared spectroscopy. Catalysed esterification of butan-l-ol by acetic acid. Analyst, 125, 2059-2064 (2000). 

J. Rantanen, H. Wikstrom, R. Turner, and L.S. Taylor, Use of in-line near-infrared spectroscopy in combination with chemometrics for improved understanding of pharmaceutical processes. Anal. Client., 77(2), 556-563 (2005). 

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