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Process control and sampling

The master records should also indicate the sampling and test procedures involved with in-process control and sampling procedures for finished drug products... [Pg.640]

Fiber-Optic Probes. Fiber-optic probes provide remote sampling capabilities to Raman instmmentation, are stable, and give reproducible signals. Their historical niche has been in environmental monitoring. More recently these probes have been used in chemical process control and related areas such as incoming materials inspection. [Pg.213]

Stirred bioreactors are common in animal cell culture, as they offer a homogenous enviroiunent, representative sampling, better access to process control and an increased oxygen transfer. Several of these techniques (spinner flasks and stirred vessel bioreactors) have been tested successfully for the cultivation of hematopoietic cells [58,64-67]. [Pg.122]

The surface of a solid sample interacts with its environment and can be changed, for instance by oxidation or due to corrosion, but surface changes can occur due to ion implantation, deposition of thick or thin films or epitaxially grown layers.91 There has been a tremendous growth in the application of surface analytical methods in the last decades. Powerful surface analysis procedures are required for the characterization of surface changes, of contamination of sample surfaces, characterization of layers and layered systems, grain boundaries, interfaces and diffusion processes, but also for process control and optimization of several film preparation procedures. [Pg.277]

The in-process inspection and testing is carried out in accordance with the approved test methods, work instmctions, and qualified equipment. For in-process control, statistical sampling techniques are used as appropriate. [Pg.229]

For in-process control and determination of quality levels, inspection plans and quality control charts are used (as relevant). For sampling plans and acceptance criteria. Military Standard 105E is used. [Pg.411]

In 1995, Taylor and co-workers also described the use of an open-access LC/MS system for routine structure confirmation, featuring atmospheric pressure chemical ionization (APCI). This system featured dual personal computers (PCs) for automated instrument control and sample log-in. A system-PC is responsible for running the Windows NT for Workgroups operating system and interfaces with the network for instrument control. A separate log-in PC, isolated from the LC/MS system, is used by the synthetic chemist to enter details about the samples. The analyst prepares the sample in an autosampler vial in one of several solvent options. The system specifies where to place the sample vial in the autosampler, and following analysis with a standard method, spectra are automatically processed and printed without any chemist intervention. [Pg.98]

DOW in Midland, USA, performed metallocene-catalyzed polymerization of ethylene using a homebuilt tube reactor setup with advanced microflow tailored plant peripherals for heating, temperature monitoring, pressure control and dosing via smart valves and injectors. Screening of process conditions was a driver [19]. Also, flexibility with regard to temperature and pressure at low sample consumption was an issue. Quality of the information is another motivation due to the advanced process control and sensing. [Pg.219]

The effects that changes will have on the product at critical control points, in-process controls, and downstream steps must be considered and evaluated whenever possible. Samples from intermediate process steps may provide material that can be better evaluated for possible impurities or, in some cases, infectious agents. The milieu in which material is applied to purification... [Pg.168]

The controller receives the on-line composition measurement of the product outlets (extract and raffinate) as feedback data from the plant. These measurements are filtered through a periodic Kalman filter and used together with the simplified SMB model results to estimate the state of the system and to remove the possible moidel errors. The formulation of RMPC is based on the assumption that possible errors or disturbances are likely to repeat and will have a periodic effect on the output, which is the most likely correlation between disturbances and output in a SMB unit. The estimated future concentration profile in the SMB is used to optimize the future behaviour of the plant over a predefined prediction horizon. The controller implements the calculated optimal plant input by changing the external flow rates in order to control the internal flow rates, which are the manipulated variables. Time lags, e.g. between online concentration measurements and optimizer or between optimizer and SMB plant, are insignificant relative to the process dynamics and sampling time for the planned scheme. [Pg.178]

Morabito PL and Melcher RG. Automated membrane/gas chromatography system for extraction and determination of trace organics in aqueous samples using large volume injection. Process Control and Quality 1992 3 35 2. [Pg.367]

To assure batch uniformity and integrity of drug products, written procedures shall be established and followed that describe the in-process controls, and tests, or examinations to be conducted on appropriate samples of in-process materials of each batch. [Pg.159]

Who Should Develop Immunoassays The answer to this question is simple - everyone. The more complex question is once these assays are developed how do we get them in the hands of users Certainly the agricultural chemical industry should be involved in the development of assays for their products. Even if the assays are never used for registration, the assays will save companies money by being used in-house as research tools. In most companies there is such a backlog of residue samples to run that in-house assays to test formulation, plant distribution, process control and many other problems receive low priority. Immunoassays can have a major impact on these problems. [Pg.119]


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See also in sourсe #XX -- [ Pg.67 ]




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Process Sample

Process control and

Process sampling

Sample processing

Sampling controller

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