Procarbazine Mechlorethamine

Nitrogen mustard is clinically used for the treatment of lymphomas and some forms of lung cancer. The major indication for mechlorethamine is Hodgkin s disease as a part of the MOPP regimen (mechlorethamine + vincristine (oncovin) + procarbazine + prednisone). The usual dose consists of 6 mg/m2 on days 1 and 8. This drug has pronounced hematological toxicity (myelo-suppression). [Pg.54]

More recently, a German study compared a dose-escalated regimen of BEACOPP (with filgrastim support) with standard-dose bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone, gemcitabine (BEACOPP) and COPP alternating with ABVD (C—cyclophosphamide instead of mechlorethamine for MOPP).18 The escalated BEACOPP was... [Pg.1378]

The chemotherapy of advanced Hodgkin s disease is one of the best examples of successful combination chemotherapy. Combination therapy with the MOPP regimen (mechlorethamine, Oncovin [vincristine sulfate], procarbazine, prednisone), alternating with ABVD (Adriamycin [doxorubicin hydrochloride], bleomycin, vinblastine, dacarbazine), has resulted in cure rates of 50 to 60%. [Pg.635]

The major indication for mechlorethamine is Hodgkin s disease the drug is given in the MOPP regimen (mechlorethamine, vincristine, procarbazine, prednisone see Chapter 55). Other less reactive nitrogen mustards are now preferred for the treatment of non-Hodgkin s lymphomas, leukemias, and various solid tumors. [Pg.640]

MOPP Mechlorethamine, vincristine (Oncovin), procarbazine, prednisone MTX Methotrexate... [Pg.1160]

This is present in mechlorethamine (Mustargen), which is used in patients with Hodgkin s disease and other lymphomas, usually in combination with other drugs, such as in MOPP therapy (mechlorethamine, Oncovin [vincristine], procarbazine, and prednisone). It may cause bone marrow depression. [Pg.112]

Hodgkin s disease Mechlorethamine, Oncovin (vincristine), procarbazine, and prednisone (MOPP). [Pg.115]

Procarbazine (Matulane) inhibits DNA, RNA, and protein synthesis through the operation of an unknown mechanism. It is effective in patients with Hodgkin s disease when given in combination with mechlorethamine, vincristine, and prednisone (MOPP). Procarbazine causes neurotoxicity, bone marrow depression, and gastrointestinal injury. [Pg.581]

Hodgkin s disease (stages III and IV) Combination chemotherapy vinblastine, doxorubicin, dacarbazine, bleomycin Lomustine, etoposide, ifosfamide, interferon, mechlorethamine, vincristine, procarbazine, prednisone... [Pg.1310]

Therapeutic applications Mechlorethamine is used primarily in the treatment of Hodgkin s disease as part of the MOPP regimen (Mechlorethamine, Oncovin, Prednisone, Procarbazine), and is also useful in the treatment of some solid tumors. [Pg.399]

Procarbazine is an alkylating agent that is used in the treatment of Hodgkin s disease in regimens such as MOPP (chlormethine (mechlorethamine), vincristine (Oncovin), procarbazine, and prednisolone) and BEACOPP (bleomycin, etoposide, doxorubicin (Adriamycin), cyclophosphamide, vincristine, procarbazine, and prednisone) (1). It is also used to treat glioblastoma multiforme. [Pg.2929]

Clinically important, potentially hazardous interactions with altretamine, amikacin, aminoglycosides, antineoplastics, bleomycin, busulfan, carboplatin, carmustine, chlorambucil, cisplatin, corticosteroids, cyclophosphamide, cytarabine, dacarbazine, dactinomycin, daunorubicin, docetaxel, doxorubicin, estramustine, etoposide, fludarabine, fluorouracil, gemcitabine, gentamicin, hydroxyurea, idarubicin, ifosfamide, indomethacin, kanamycin, levamisole, lomustine, mechlorethamine, melphalan, mercaptopurine, methotrexate, mitomycin, mitotane, mitoxantrone, neomycin, pentostatin, plicamycin, procarbazine, streptomycin, streptozocin, thioguanine, thiotepa, tobramycin, tretinoin, uracil, vinblastine, vincristine, vinorelbine... [Pg.13]

One of the initial combination chemotherapy regimens introduced in the early 1960s that was shown to produce cures in advanced Hodgkin s disease was the MOPP (mechlorethamine, vincristine [Oncovin], procarbazine, and prednisone) regimen (see Table 129-6)P MOPP chemotherapy has been a mainstay of treatment for patients with stage III and IV advanced Hodgkin s disease. According... [Pg.2445]

MVPP mechlorethamine, vinblastine, procarbazine, and prednisone NCCN National Comprehensive Cancer Network NCI National Cancer Institute NHL non-Hodgkin s lymphoma... [Pg.2463]

Mechlorethamine HCl (Mustargen) was formerly used primarily in the combination chemotherapy regimen MOPP (mechlorethamine, vincristine [Oncovin], procarbazine, and prednisone) in patients with Hodgkin s disease. It is given by intravenous bolus administration in doses of 6 mg/m on days 1 and 8 of the 28-day cycles of each course of treatment. It has been largely replaced by cyclophosphamide, melphalan, and other more stable alkylating agents. It also is used topically for treatment of cutaneous T-cell lymphoma as a solution that is rapidly mixed and applied to affected areas of skin. [Pg.405]

This methyl radical generator is utilized predominantly in the treatment of Flodgkin s disease. It Is administered as part of a multidrug regimen that also includes a nitrogen mustard (mechlorethamine), a mitosis inhibitor (vincristine), and prednisone. It is administered as capsules and Is well absorbed after oral administration. Procarbazine is extensively metabolized in the liver, and 70% of an administered dose is excreted in the urine as N-isopropylterephthalamic acid (Fig. 42.10). In addition to ... [Pg.1790]

Weiss GB, Weiden PL, Thomas ED. Central nervous system disturbances after combined administration of procarbazine and mechlorethamine. Cancer Treat Rep (1977) 61, 1713-14,... [Pg.657]

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