Preparation of activated

The observation that very significant parts of the cocaine molecule could be deleted from synthetic analogs without loss of biologic activity led to the search for the minimal structural feature consistent with activity. This exercise, sometimes referred to as molecular dissection, not only led to great simpli-fi cation of the structure of local anesthetics but resulted fi-tially in the preparation of active molecules that bear only the remotest structural relation to the prototype, cocaine. 

Murashima, K., Chen, C.-L., Kosugi, A. et al. (2002) Heterologous production of Clostridium cellulovorans engB, using protease-deficient Bacillus subtilis, and preparation of active recombinant cellulosomes. Journal of Bacteriology, 184 (1), 76-81. 

Ahmadpour A., Do D.D., The preparation of active carbons from coal by chemical and physical activation, Carbon 1996 34 471-479. 

Lozano-Castello D., Lillo-Rodenas M.A., Cazorla-Amoros D., Linares-Solano A., Preparation of activated carbons from Spanish anthracite. Carbon 2001 39 741-749. 

PREPARATION OF ACTIVATED ESTERS USING CARBODIIMIDES AND ASSOCIATED SECONDARY REACTIONS... 

OTHER METHODS FOR THE PREPARATION OF ACTIVATED ESTERS OF A/-ALKOXYCARBONYLAMINO ACIDS... 

FIGURE 7.12 Preparation of activated esters of A-alkoxycarbonylamino acids by reaction of the hydroxy compound with a mixed anhydride (path A), obtained by leaving the three reagents (NMM = A-methylmorpholine) in CH2C12 at 23°C for 2 minutes.35 Mixed carbonate that is formed (path B) is readily eliminated by crystallization of the ester. 

NL Benoiton, YC Lee, FMF Chen. Preparation of activated esters of A-alkoxycarbo-nylamino and other acids by a modification of the mixed anhydride procedure. Int J Pept Prot Res 42, 278, 1993. 

D. Lozano-Castello, M. A. Lillo-Rodenas, D. Cazorla-Amoros, and A. Linares-Solano, Preparation of activated carbons from Spanish anthracite I. Activation by KOH, Carbon, 39,741-749 (2001). 

D. Lozano-Castello, D. Cazorla-Amoros, A. Linares-Solano, and D. F. Quinn, Influence of pore size distribution on methane storage at relatively low pressure preparation of activated carbon with optimum pore size, Carbon, 40,989-1002 (2002). 

Takenaka, S., et al., Coverage of carbon nanotubes with titania nanoparticles for the preparation of active titania-based photocatalysts. Applied Catalysis B Environmental, 2012. 125(0) p. 358-366. 

H. Bonnemann, W. Brijoux, R. Brinkmann, E. Dinjus, T. Jouben, R. Fretzen, and B. Korall, Highly dispersed metal clusters and colloids for the preparation of active liquid-phase hydrogenation catalysts, J. Mol. Catal. 74,323-333 (1992). 

Preparation of Active Metals from Metals their Salts and Complexes... 

Figure 3.19 Process for preparation of activated polymeric surfaces. (From Lee, P.H. et al.. Bioconjugate Chem., 13, 97-103, 2002. With permission.)...

Different syntheses of y-amino-/3-ketoeter derivatives from iV-protected L-aminoacids by Al,Al -carbonyldiimidazole activation and treatment with the magnesium enolate of hydrogen ethyl malonate are described. These compounds are useful intermediates in the preparation of active amino acid analogues, as illustrated and summarized in equation 103. 

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