Prednisone therapy

Blum AS, Dal Pan GJ et al (1996) Low-dose zalcitabine-related toxic neuropathy frequency, natural history, and risk factors. Neurology 46(4) 999-1003 Bradley WG, Verma A (1996) Painful vascuhtic neuropathy in HlV-1 infection relief of pain with prednisone therapy. Neurology 47(6) 1446-1451 Breen EC (2002) Pro- and anti-inflammatory cytokines in human immunodeficiency virus infection and acquired immunodeficiency syndrome. Pharmacol Ther 95(3) 295-304 Bremer J (1990) The role of carnitine in intracellular metabolism. J Clin Chem Clin Biochem 28(5) 297-301... 

Progressive endometrial carcinoma associated with azathioprine and prednisone therapy has been reported (359). 

Rapid progression of Kaposi s sarcoma 10 weeks after combined treatment with glucocorticoids and cyclophosphamide has been described marked improvement of the skin lesions was noted after discontinuation of prednisone therapy (360). 

Kaye LD, Kalenak JW, Price RL, Cunningham R. Ocular implications of long-term prednisone therapy in children. J Pediatr Ophthalmol Strabismus 1993 30(3) 142-4. Cumming RG, Mitchell P, Leeder SR. Use of inhaled corticosteroids and the risk of cataracts. N Engl J Med 1997 337(1) 8-14. 

In recent years, two multicenter experiments were conducted with oral prednisone therapy in patients undergoing coronary bare-metal stent implantation (44,45). 

B. Oral prednisone therapy, tapered down over 2 weeks... 

Glucocorticoids can cause neuropsychiatric adverse effects that dictate a reduction in dose and sometimes withdrawal of treatment. Of 32 patients with asthma (mean age 47 years) who took prednisone in a mean dosage of 42 mg/day for a mean duration of 5 days, those with past or current symptoms of depression had a significant reduction in depressive symptoms during prednisone therapy compared with those without depression... 

Posterior subcapsular cataracts (PSCs) can occur with all routes of administration (Figure 12-2), including systemic, topical, cutaneous, nasal aerosols, and inhalation corticosteroids. In a study of 44 rheumatoid arthritis patients treated with various steroids, including prednisone and dexamethasone, 17 (39%) developed bilateral PSCs. Dosage and duration of therapy appeared to be correlated with the incidence of cataract development. Patients who received prednisone therapy for 1 to 4 years showed an 11% incidence if the dose range was less than 10 mg/day a 30% incidence if the dose was... 

MacGregor RR, Sheagren HN, Lipsett MD,Wolff SM.Alternate day prednisone therapy. N EnglJ Med 1969 280 1427-1431. 

Czaja, A.J., Wang, K.K., Shiels, M.T., Katzmann, J.H. Oral pulse prednisone therapy after relapse of severe autoimmune chronic active hepatitis. J. Hepatol. 1993 17 180-186... 

Kaye LD, Kalenak JW, Price RL, Cunningham R. Ocular implications of long-term prednisone therapy in children. J Pediatr Ophthalmol Strabismus 1993 30(3) 142-4. 

Park CL, Frank AL, Sullivan M, Jindal P, Baxter BD. Influenza vaccination of children during acute asthma exacerbation and concurrent prednisone therapy. Pediatrics 1996 98(2 Pt l) 196-200. 

In a retrospective analysis in 51 children with glucocorticoid-dependent nephrotic sjmdrome, the ability of levamisole to reduce the relapse rate and to spare prednisone therapy was compared with that of cyclophosphamide (21). Apart from one patient who had a spontaneously resolving skin rash with levamisole and three patients who had transient neutropenia with cyclophosphamide, there were no other clinically significant adverse effects. 

About 2 weeks after receiving a second dose of adsorbed tetanus toxoid a 50-year-old woman developed generalized morphea, a rare condition, in which multiple patches of skin sclerosis occur over much larger areas than in the localized variant. The patient denied taking any drugs. After prednisone therapy, a month later the lesions had dramatically improved (12). 

In five patients with prior normal renal function, zomepirac caused acute renal insufficiency, with varying degrees of uremia, proteinuria, and oliguria (5). All recovered either after withdrawal or with prednisone therapy. In another case renal biopsy showed a tubulointerstitial nephritis (6). 

Almost all commercial radioimmunoassay methods for serum cortisol show some cross-reactivity with prednisolone. Because prednisone is converted to prednisolone in vivo, these kits cannot be used to analyze specimens from patients on prednisone therapy. The degree of crossreactivity with 11-DOC, corticosterone, and prednisone varies from 1% to 5% these cross-reactions are antiserum dependent. When high plasma concentrations of 11-DOC are found (such as in lip-hydroxylase deficiency or after administration of metyrapone), prefiminary extraction with carbon tetrachloride to remove this steroid is usually indicated. 

Eigen H, Rosenstein BJ, FitzSimmons S, et al. A multicenter study of alternate-day prednisone therapy in patients with cystic fibrosis. J Pediafr 1995 126 515-523. 

No prospective treatment trials have been reported. However, prednisone therapy in a dose of 1 mg/kg daily for 4 weeks has been used and may improve the rate and extent of renal recovery. ... 

A20. Avioli, L. V., Lasersohn, J. T., and Lopresti, J. M., HistiocytcBis X (Schuller-Christian disease) A clinico-pathological survey, review of ten patients and the results of prednisone therapy. Medicine 42, 119-147 (1963). 

Silver RM, Warrick JH, Kinsella MB, et al. Cyclophosphamide and low-dose prednisone therapy in patients with systemic sclerosis (scleroderma) with interstitial lung disease. J Rheumatol 1993 20 838-844. 

Moran TJ, Totten RS. Lymphoid interstitial pneumonia with dysproteinemia. Report of two cases with plasma cell predominance. Am J Clin Pathol 1970 54(5) 747-756. Kohler PF, Cook RD, Brown WR, et al. Common variable hypogammaglohuUnemia with T-ceU nodular lymphoid interstitial pneumonitis and B-ceU nodular lymphoid hyperplasia different lymphoc3de populations with a similar response to prednisone therapy. J AUergy Chn Immunol 1982 70(4) 299-305. 

An individual case of a 45-year-old female with multiple sclerosis who presented to the emergency department with symptomatic sinus bradycardia after the completion of a high-dose oral prednisone therapy for multiple sclerosis-related optic neuritis has been reported [6 ]. She received l,250mg of oral prednisone per day for 5days in total and finished her course 3 days before her emergency department presentation. The patient s pulse rate and symptoms resolved on their own a week after the completion of the high-dose prednisone. There are very few adult cases that report this side effect and all of them have been with intravenous methylprednisolone. This is the first case report of a patient with symptomatic bradycardia from an oral CS regimen. 

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