Asthma pharmacogenetics

PiUai, S. G., Cousens, D. J., Barnes, A. A., et al. (2004) A coding polymorphism in the CysLTj receptor with reduced affinity to LTD is associated with asthma. Pharmacogenetics. 14,627-633. 

Fukai, H., Ogasawara, Y., Migita, O., et al. (2004) Association between a polymorphism in cysteinyl leukotriene receptor 2 on chromosome 13ql4 and atopic asthma. Pharmacogenetics. 14,683-690. 

The classic example of an asthma pharmacogenetic candidate gene is ADRP2 (Pj-adrenergic receptor). The P -adrenergic receptor agonists, such as the short-acting... 

A classic example of a biological pathway with implications for asthma pharmacogenetics is the leukotriene synthesis pathway. Cysteinyl leukotrienes... 

Asano K, Shiomi T, Hasegaw a N, et al Leukotriene C4 synthase gene A(-444)C polymorphism and clinical response to a CYS-LT( l) antagonist, pranlukast, in Japanese patients with moderate asthma. Pharmacogenetics 2002 12 565-570. (Ila)... 

Montine TJ, Montine KS (2015) Precision medicine clarity for the clinical and biological complexity of Alzheimer s and Parkinson s diseases. J Exp Med 212 601-605 Ortega VE, Meyers DA, Bleecker ER (2015) Asthma pharmacogenetics and the development of genetic profiles for personalized medicine. Pharmgenomics Pers Med 8 9-22 Prados MD, Byron SA, Tran NL et al (2015) Toward precision medicine in glioblastoma the promise and the challenges. Neuro Oncol 17 1051—1063... 

Drazen JM, Yandava CN, Dube L, SzCZERBACK N, HlPPENSTEEL R, PlLLARI A et al. Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment. Nature Genet 1999 22[2] 168-170. 

Tab. 10.1 Pharmacogenetic mechanisms with implications for asthma treatment...

Drazen, J., et al., "Pharmacogenetic Association Between ALOX5 Promoter Genotype and the Response to Anti-Asthma Treatment," Nat. Genet., 22, 168-170 (1999). 

Liggett, S.B., "The Pharmacogenetics of Beta2-Adrenergic Receptors Relevance to Asthma," /. Allergy Clin. Immunol, 105, 487-492 (2000). 

Liggett, S.B., The pharmacogenetics of beta 2-adrenergic receptors-relevance to asthma, /. Asthma, 105, S487-S492, 1999. 

Table 11.1 Examples of asthma drug response pathways and pharmacogenetic target genes...

Choudhry S, Ung N, Avila PC, et al. (2005) Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med. 171, 563-570. 

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