Pre-B cells

Immunologic phenotype Early pre-B cell Null cell,T cell, pre-B cell, B cell... 

Nagasawa T, Kikutani H, Kishimoto T. Molecular cloning and structure of a pre-B-cell growth-stimulating factor. Proc Natl Acad Sci U S A 1994 91 2305-2309. 

Egawa T, Kawabata K, Kawamoto H, et al. The earliest stages of B cell development require a chemokine stromal cell-derived factor/pre-B cell growth-stimulating factor. Immunity 2001 15 323-334. 

Filippini, G. et al., Flow cytometric detection of p53 protein after incubation of a pre-B cell line with antitumor agents, Cytometry, 35, 267, 1999. 

Yamaguchi, K., et. al., Activation of the aryl hydrocarbon receptor/transcription factor and bone marrow stromal cell-dependent pre-B cell apoptosis, J. Immunol., 158, 2165,1997. 

Vaux, D.L., Cory, S., and Adams, J.M., 1988, Bd-2 gene promotes hemeopoietic ceU survival and cooperates with c myc to immortalize pre-B cells. Nature 325 440-442... 

Rodig SJ, Rutok IL, Paterson IC et al (2010) The pre-B-cell receptor associated protein VpreBS is a useful diagnostic marker for identifying c-MYC translocated lymphomas. Haematologica 95 2056-2062... 

The B cell goes through several stages of development, beginning with the Pro-B cell, followed by the Pre-B cell, which in turn matures into a B cell bearing a mature immunoglobulin-M (IgM) B cell receptor on the cell surface. The population of... 

Costinean S, Zanesi N, Pekarsky Y et al. Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice. Proc Natl Acad Sci USA 2006 103 7024-7029. Volinia S, Calin GA, Liu CG et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 2006 103 2257-2261. 

The involvement of the pre-B cell receptor in allelic exclusion at the heavy chain locus is reminiscent of the original suggestion of Alt et al. (1980a) that surface IgM... 

Not all data favored stepwise linear deletion as the basis for switching. Obata et al. (1981) found that the DNA organization in a particular plasmacytoma could be explained by unequal sister chromatid exchange, but observations inconsistent with this possibility were reported by Wabl et al. (1985). Alt et al. (1982) observed that a subclone of a transformed pre-B cell line had switched from synthesis of a p chain to synthesis of a y chain, with retention of the same VH and JH as well as both copies of the gene these results suggested that the switch in heavy chain synthesis was a transcriptionally controlled event (see discussion below). 

Blackwell, T.K., Malynn, B.A., Pollock, R.R., Fenier, P., Covey, L.R., Fulop, G.M., Phillips, R.A., Yancopoulos, G.D., Alt F.W. (1989). Isolation of scid pre-B cells that rearrange kappa light chain genes formation of normal signal and abnormal coding joins. EMBO J. 8,735-742. 

Burrows, P., Lejeune, M., Kearney, J.F. (1979). Evidence that murine pre-B cells synthesize p heavy chains but no light chains. Nature 280, 838-841. 

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