Cancer defined

Schiller JH. Small cell lung cancer defining a role for emerging platinum drugs. Oucology 2002 63(2) 105-14. 

Scher HI, Mazumdar M, Kelly WK. Chnical trials in relapsed prostate cancer Defining the target. J Natl Cancer Inst 1996 88 1623-1634. 

These are interesting and provocative questions for the care of the breast cancer patient. The American Joint Commission on Cancer defines micrometastasis as a cluster of cells that are no larger than 2 mm. Recent studies with more than 10 years of follow-up conclude that micrometastases are associated with a small but statistically significant decrease in tumor-free survival and overall survival when compared with truly nodenegative cases, but they are not an independent prognostic factor. The size of the metastatic deposit, taken together with tumor size and other factors, may additionally stratify patients at risk for further disease. 

Categories from Cheang MC, Voduc D, Bajdik C, et al. Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype. Clin Cancer Res. 2008 14 1368-1376. 

Fradet Y, Cordon-Cardo C, Thomson T, Daly ME, Whitmore WF Jr, Lloyd KO, Melamed MR, Old U. Cell surface antigens of human bladder cancer defined by mouse monoclonal antibodies. Proc Natl Acad Sci USA 1984 81 224-228. 

Chemiluminescence has been studied extensively (2) for several reasons (/) chemiexcitation relates to fundamental molecular interactions and transformations and its study provides access to basic elements of reaction mechanisms and molecular properties (2) efficient chemiluminescence can provide an emergency or portable light source (J) chemiluminescence provides means to detect and measure trace elements and pollutants for environmental control, or clinically important substances (eg, metaboHtes, specific proteins, cancer markers, hormones, DNA) and (4) classification of the hioluminescent relationship between different organisms defines their biological relationship and pattern of evolution. 

In the veterinary as in the human patient, neoplasms are often metastatic and widely disseminated throughout the body. Surgery and irradiation are limited in use to weU-defined neoplastic areas and, therefore, chemotherapy is becoming more prevalent in the management of the veterinary cancer victim (see Chemotherapeutics, anticancer). Because of the expense and time involved, such management must be restricted to individual animals for which a favorable risk—benefit evaluation can be made and treatment seems appropriate to the practitioner and the owner. In general, treatment must be viewed not as curative, but as palliative. 

In 1971, levamisole, an anthelmintic compound widely used in catde and swine, was shown to improve the effects of an experimental Brucella abortus vaccine in mice. Since that time, the veterinarians and physicians have explored the effects of levamisole in such diverse areas as arthritis, lupus erythematosis, cancer therapy, respiratory diseases, Newcastle disease, foot-and-mouth disease, mastitis, and vaccine potentiation. Although the exact mechanism of action has as yet not been deterrnined there is substantial evidence that, under defined circumstances, levamisole can augment the animal s natural immune response (9). New immunostimulants include Staph Ijysate acemannon, NLAB-31. 

Hazard identification is defined as tlie process of determining whetlier human exposure to an agent could cause an increase in the incidence of a health condition (cancer, birtli defect, etc.) or whetlier exposure to nonliumans, such as fish, birds, and otlier fonns of wildlife, could cause adverse effects. Hazard identification cliaracterizes tlie liazard in terms of tlie agent and dose of the agent. Since tliere are few hazardous chemicals or hazardous agents for wliich definitive exposure data in humans exists, tlie identification of health hazards is often characterized by the effects of health hazards on laboratory test animals or other test systems. ... 

Semaphorins are secreted, membrane-associated or transmembrane proteins defined by the presence of a sema-phorin protein domain (Serna domain). In the mammalian system, more than 20 semaphorins have been identified which play important roles in a variety of tissues. The best characterized receptors for mediating semaphoiin effects are members of the neuropilin and plexin families of transmembrane proteins. Semaphoiin functions are best described in the regulation of neural development, angiogenesis, immunoregulation and cancer. 

The Orphan Drug Act of 1983 was passed to encourage die development and marketing of products used to treat rare diseases. The act defines a rare disease as a condition affecting fewer than 200,000 individuals in die United States. The National Organization of Rare Disorders reports that there are more tiian 6000 rare disorders that affect approximately 25 million individuals. Examples of rare disorders include Tourette s syndrome, ovarian cancer, acquired immunodeficiency syndrome (AIDS), Huntington s disease, and certain forms of leukemia... 

Health Effect The major categories of health effects included in LSE tables and figures are death, systemic, immunological, neurological, developmental, reproductive, and cancer. NOAEEs and EOAELs can be reported in the tables and figures for all effects but cancer. Systemic effects are further defined in the "System" column of the LSE table (see key number 18). 

The Chemical Substances Threshold Limit Values Committee classifies certain substances found in the occupational environment as either confirmed or suspected human carcinogens. The present listing of substances that have been identified as carcinogens takes two forms those for which a TLV has b n assigned and those for which environmental and exposure conditions have not been sufficiently defined to assign a TLV. Where a TLV has been assigned, it does not necessarily imply the existence of a biological threshold however, if exposures are controlled to this level, we would not expect to see a measurable increase in cancer incidence or mortality. 

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