Pramoxine hydrochloride

20 g 4,4-diphenyl-cyclohexen-(2)-one, 10 g isopropylamine, and 50 ml tetrahydrofuran are agitated for 10 hours in a bombtube at 200°C. Subsequently, the reaction mixture is cooled, and the tetrahydrofuran and the excess isopropylamine are distilled off. The remaining Schiff base is dissolved in methanol and after the addition of 2 g platinum oxide, the base is hydrogenated at normal pressureand room temperature until a quantity of hydrogen corresponding to 2 mols has been absorbed. 

The mixture is filtered off from the catalyst, made acidic with dilute hydrochloric acid, and the methanol is removed under vacuum. The remaining aqueous solution is made alkaline with solution of sodium hydroxide and extracted with ether. After drying and concentrating the ether extract, there is obtained 17 g 1-isopropylamino-4,4-diphenyl-cyclohexane, boiling point 164°C to 165°C/0.05 mm. The hydrochloride melts at 230°C. 

Chemical Name 4-[3-(4-Butoxyphenoxy)propyl] morpholine hydrochloride Common Name Pramocaine hydrochloride proxazocain hydrochloride Structural Formula  

Trade Name Manufacturer Country Year Introduced 

Wright, H.B. and Moore, M.B. U.S. Patent 2,870,151 January 20, 1959 assigned to Abbott Laboratories 

---

Pramoxine hydrochloride is a topical anesthetic that can provide temporary relief from pruritus associated with mild eczematous dermatoses. Pramoxine is available as a 1% cream, lotion, or gel and in combination with hydrocortisone acetate. Application to the affected area two to four times daily may provide short-term relief of pruritus. Local adverse effects include transient burning and stinging. Care should be exercised to avoid contact with the eyes. 

Bacitracin neomycin sulfate, polymyxin B sulfate pramoxine hydrochloride Neosporin plus pain relief Liquid paraffin, microcrystalline wax, propylene glycol... 

Anti-inflammatory Hydrocortisone acetate, pramoxine hydrochloride Pramosone Mineral oil and PEG... 

Gas chromatographic methods have been developed to solve this problem. Theophylline has been gas chromatographed and determined as such, but in most cases derivatization has been carried out to obtain better gas chromatographic properties and better detection possibilities. For quantitative work several substances have been used as internal standard, mainly barbiturates (alphenal, amobarbital, aprobarbital, heptabarbital, hexabarbital, thiobarbital), but also other substances have been used (fluoranthene, codeine, theobromine, medazepam, pramoxine hydrochloride, cyheptamine, probenecid propylester). Recently 3-isobutyl-1-methyl... 

Topical antibiotic treatments typically also include a local anesthetic (numbing agent), such as pramoxine hydrochloride, that interferes with the function of nerves that sense pain. 

Hydrocortisone Acetate and Pramoxine Hydrochloride Cream and Lotion... 

Pramoxine Hydrochloride and Zinc Acetate Lotion and Ointment... 

The lotion contains pramoxine hydrochloride 1% and zinc acetate 0.1% and inactive ingredients alcohol USP, camphor, citric acid, diazolidinyl urea, fragrance, glycerin, hydroxypropyl methylcellulose, methylparaben, oil of lavender, oil of rosemary, polysorbate 40, propylene glycol, propylparaben, purified water, and sodium citrate. The... 

Slowly add pramoxine hydrochloride to step 3 and premix using homomixer or similar. Take precaution to minimize spread of powder to adjacent areas. 

---