Morpholine hydrochloride

The acetylene aminopyrazole 103 was capable of inhibiting the processes of lipid peroxidation both in the enzymatic and nonenzymatic peroxidation system (76MI2). Finally, 4-[3-(l-methyl-l//-pyrazol-3-yl)-prop-2-ynyl]morpholine hydrochloride 104 was patented as a compound with high hypoxic activity (93MIP1). 

The side chain hydroxy group of 3-(2-hydroxyethyl)-2-methyl-9-methoxy-4//-pyrido[l,2-u]pyrimidin-4-one, and that of its 6,7,8,9-tetrahydro derivative was acylated with MeS02Cl in the presence of NEts in CH2CI2 at room temperature (95MIP4, 96MIP2). The hydroxy group of 2-[4-(4-hydro-xybenzoyl)benzyloxy]-3-methyl-4//-pyrido[l, 2-u]-pyrimidin-4-one, its 6-methyl derivative and 2-[4-(4-hydroxybenzoyl)benzylthio]-3-methyl-4//-pyrido[l, 2-u]pyrimidin-4-one was alkylated with 4-(2-chloroethyl)morpholine hydrochloride and 4-picolyl chloride hydrochloride (96EUP733633). 

Chemical Name 4-[3-(4-Butoxyphenoxy)propyl] morpholine hydrochloride Common Name Pramocaine hydrochloride proxazocain hydrochloride Structural Formula ... 

Chemical (Marne 2-[(2-ethoxyphenoxy)methyl] morpholine hydrochloride Common Name —... 

A solution 35.6 g of 4-chlormethyl-6,7-dihydroxycoumarin and 27.3 g of morpholine in 4.5 L methyl ethyl ketone was refluxed for 9 hours. On cooling the morpholine hydrochloride was deleted. Methyl ethyl ketone was evaporated in vacuum. The solid product was mixed with 500 ml of water and dried in vacuum with P205. Yield of crude 6,7-dihydroxy-4-(morpholinomethyl)coumarin is 41.5 g. After recrystallization from ethanol was obtained 6,7-dihydroxy-4-(morpholinomethyl)coumarin with M.P. 232°C. 

Ethyl phenthiazine-2-carbamate 3-Chloropropionyl chloride Morpholine hydrochloride... 

To a solution of the product from Step 3 (9.08 mmol) dissolved in 30 ml N,N-dimethylformamide was added 4-(2-chloroethyl)morpholine hydrochloride (27.2 mmol) and K2CO3 (27.2 mmol). Thereafter, the solution was heated to 63 °C 24 hours. Additional K2CO3 (9.08 mmol) and 4-(2-chloroethyl)-morpholine hydrochloride (9.08 mmol) were added and the mixture re-heated for an additional 24 hours at 63 °C. The mixture was partitioned between EtOAc and water, the organic phase washed 3 times with 30 ml brine, dried, and concentrated. The residue was purified by flash chromatography using EtOAc/hexane, 2 8, and 5.21 g product isolated. MS and elemental analysis data supplied. 

N-(2-CHLOROETHYL)-N-(l-METHYL-2-PHENOXYETHYL)BENZENEMETHAN AMINE HYDROCHLORIDE see DDG800 N-(2-CHLOROETHYL)-N-(l-METHYL-2-PHENOXYETHYL)BENZYLAMINE see PDT250 N-(2-CHLOROETHYL)-N-(l-METHYL-2-PHENOXYETHYL)BENZYLAMINE HYDROCHLORIDE see DDG800 4-(2-CHLOROETHYL)MORPHOLINE HYDROCHLORIDE see CHEOOO... 

Bis[morpholino] tellurium dichloride in dichloromethane oxidized hydroquinones quickly to quinones, thiols quickly to disulfides, and 2,6-di- -butylphenol slowly to a dipheno-quinone. The by-products are eiementai tellurium and morpholine hydrochloride. ... 

A quantitative IR absorption for the two polymorphs of the developmental compound (2R,3S)-2-( (lR)-l-[3,5-feis(trifluoromethyl)phenyl] ethyl oxy)-3-(4-fluorophenyl) morpholine hydrochloride was reported in which the measurements were made in mineral oil mull preparations.58... 

In a 250 mL three-necked flask a mixture of 16.2 g (130 mmol) of chloroacetaldehyde, dimethyl acetal and 20 mL of 0.75 N hydrochloric acid was heated to gentle reflux until a homogenous solution resulted (approx. 20 min required). To this hot solution, the previously prepared morpholine hydrochloride solution was added dropwise and thereafter the mixture was cooled to 5 -10 °C. 

Morpholine added to dichloracetic acid, excess morpholine then removed, the remaining mixture of morpholinium dimorpholinoacetate and morpholine hydrochloride dissolved in acetic acid containing ca. 10% water with ice-cooling, which is also maintained during the subsequent dropwise addition of the resulting mixture to coned. H2SO4 and 10-20%-oleum, the temp, of the bath raised towards the end of the reaction if necessary di-p-methoxyphenylacetic acid. Y 74%. F. e. and limitations s. A. Brault and M. Kerfanto, G. r. 258, 5465 (1964). 

N-Acetyl-h-alanyl-L-alanyl-h-prolyl-ij-vChloromethyl Ketone (Ac-Ala-Ala-Pro-ValCH,Cl) The diazomethyl ketone Boc-ValCHNa is prepared from Boc-Val-OH (10 g, 45 mmoles) by the mixed anhydride method (M -methylmorpholine, 45 mmoles isobutyl chloroformate, 45 mmoles) in tetrahydrofuran at —10° to —15°. The mixed anhydride solution is filtered under anhydrous conditions to remove Al-methyl-morpholine hydrochloride and is then added to excess CHaN in ether. After standing overnight at room temperature, anhydrous HCl is bubbled through the solution of Boc-ValCHNo at 5° for 15 min as the solution turns from yellow to colorless. The product (HCl-ValCHaCl) is isolated by evaporation of the solvents and dried under reduced pressure to give 4.5 g (55%) of an extremely hydroscopic white solid. 

---