Pramoxine

As shovm above, the attachment of the aromatic ring to the carbon chain bearing the basic nitrogen may be accomplished through an ester or an amide configured in either direction. A simple ether linkage fulfills this function in yet another compound that exhibits local anesthetic activity. Thus, alkylation of the mono potassium salt of hydroquinone with butyl bromide affords the ether (77) alkylation of this with w-C3-chloropropyl)morpholine affords pramoxine (78)... 

Cream Pramoxine 1%, hydrocortisone 1% [30 gm] Apply to affected area(s) tid-qid... 

Pramoxine (Anusol Ointment, ProctoFoam-NS) Pramoxine Hydrocortisone (Enzone, ProctoFoam-HC, others)... 

Pramoxine (Anusol Ointment, PrectoFoam NS, Others) [Topical Anesthetic] Uses Relief of pain itching from hemorrhoids, anorectal surg y topical for bums dermatosis Action Topical anesthetic Dose Apply freely to anal area q3h Caution [C, ] Disp Foam (Proctofoam-NS), cream, oint, lotion, gel, pads, spray SE Contact dermatitis, mucosal thinning w/ chronic use EMS None OD Unlikely... 

Pramoxine + HydroAnti-inflammatory] Uses Relief of pain ... 

Other chemical types are available including ethers (pramoxine), ketones (dyclonine), and phenetidin derivatives (phenacaine). 

Topical local anesthesia is often used for eye, ear, nose, and throat procedures. Satisfactory topical local anesthesia requires an agent capable of rapid penetration across the skin or mucosa, and with limited tendency to diffuse away from the site of application. Cocaine, because of its excellent penetration and local vasoconstrictor effects, has been used extensively for ear, nose and throat (ENT) procedures. Cocaine is somewhat irritating and is therefore less popular for ophthalmic procedures. Recent concern about its potential cardiotoxicity when combined with epinephrine has led most otolaryngology surgeons to switch to a combination containing lidocaine and epinephrine. Other drugs used for topical anesthesia include lidocaine-bupivacaine combinations, tetracaine, pramoxine, dibucaine, benzocaine, and dyclonine. 

Pramoxine hydrochloride is a topical anesthetic that can provide temporary relief from pruritus associated with mild eczematous dermatoses. Pramoxine is available as a 1% cream, lotion, or gel and in combination with hydrocortisone acetate. Application to the affected area two to four times daily may provide short-term relief of pruritus. Local adverse effects include transient burning and stinging. Care should be exercised to avoid contact with the eyes. 

Neomycin sulfate polymyxin b sulfate, pramoxine hcl Neosporin... 

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