Potential Beneficial Effects

In recent years there has been a renewed appreciation of potential beneficial effects of roughness on a macroscale. For example Morris and Shanahan worked with sintered steel substrates bonded with a polyurethane adhesive [61]. They observed much higher fracture energy for joints with sintered steel compared with those with fully dense steel, and ascribed this to the mechanical interlocking of polymer within the pores. Extra energy was required to extend and break these polymer fibrils. 

Besides NO, other sGC-activating substances have been reported Carbon monoxide (CO) is known to bind to heme groups with high affinity but has been shown to activate the enzyme only marginally (three- to fivefold). The compound YC-1 ([3-(5 -hydroxymethyl-2 -fury 1)-1-benzyl indazole]) is a prototype of a new class of so-called NO-sensitisers. YC-1 causes a tenfold activation of NO-sensitive GC. Pharmacologically more interesting, YC-1 increases GC s sensitivity towards NO and CO suggesting potential beneficial effects of... 

Thiazide diuretics decrease urinary calcium excretion and may decrease bone turnover. However, their effects on bone mineral density and fracture rates have not been studied in controlled trials. Thiazide diuretics are not recommended solely for potential beneficial effects in osteoporosis. 

It is also known that many B-group elements, Hg, Tl, Pb for example, are poisonous. In this article we shall not refer to them again until the concluding section as we shall be concerned to show potential beneficial effects of inorganic drugs. 

Given the large number of potential beneficial effects of lowering the nominal operating temperature of the SOFC stack and their corollary affect on system cost, intermediate temperature SOFC concepts are being pursued by many organizations throughout the U.S. and the World. 

Potential beneficial effects of secondary plant compounds... 

Fischer-Tropsch synthesis making use of cobalt-based catalysts is a hotly persued scientific topic in the catalysis community since it offers an interesting and economically viable route for the conversion of e.g. natural gas to sulphur-free diesel fuels. As a result, major oil companies have recently announced to implement this technology and major investments are under way to build large Fischer-Tropsch plants based on cobalt-based catalysts in e.g. Qatar. Promoters have shown to be crucial to alter the catalytic properties of these catalyst systems in a positive way. For this reason, almost every chemical element of the periodic table has been evaluated in the open literature for its potential beneficial effects on the activity, selectivity and stability of supported cobalt nanoparticles. 

Taxol has both harmful and potentially beneficial effects. List and discuss both of these. What is the source of taxol ... 

Sildenafil was the first oral treatment for ED and is the most extensively evaluated (35). Overall success rates in patients with cardiovascular disease of 80% or greater have been recorded with no evidence of tolerance, Patients with diabetes with or without additional risk factors, with their more complex, and extensive pathophysiology, have an average success rate of 60%. In randomized trials to date, open-label or outpatient monitoring studies the use of sildenafil is not associated with any excess risk of myocardial infarction, stroke, or mortality (38-40), In patients with stable angina pectoris there is no evidence of an ischemic effect due to coronary steal, and in one large, double-blind, placebo-controlled, exercise study sildenafil 100 mg increased exercise time and diminished ischemia (41), A study of the hemodynamic effects in men with severe CAD identified no adverse cardiovascular effects and a potentially beneficial effect on coronary blood flow reserve (42), Studies in patients with and without diabetes have demonstrated improved endothelial function acutely and after long-term oral dose administration, which may have implications beyond... 

The use of testosterone replacement therapy for the treatment of hypogonadism and ED may assist PDE5 inhibitors if they have failed to be effective (57). Testosterone levels within the normal range have neutral or potentially beneficial effects on the cardiovascular system (58). Androgen replacement therapy should be offered to men with CAD and hypogonadism if symptomatically appropriate. The absence of long-term studies needs to be addressed in terms of possible preventive properties on the vascular wall, reduction in low-density lipoprotein levels, and the reduction of insulin resistance in contrast to the increase in hematocrit and risk of exacerbating prostate cancer. 

A number of studies have shown that a-tocopherol has a role in modulation of gene expression and regulation of cell proliferation (Section 4.3.3), suggesting that the potential beneficial effects of vitamin E against heart disease and cancer (Section 4.6.2) may not be because of its antioxidant action. 

A potentially beneficial effect of lidocaine has been studied in a randomized, double-blind, placebo-controlled study of the effects of preinstillation of lidocaine on tro-picamide-induced mydriasis (32). Pupillary diameter was significantly increased by the instillation of lidocaine before tropicamide. It was thought that lidocaine can enhance intraocular penetration and hence potentiate the effect of tropicamide. 

Four major potential beneficial effects of isoflavones include heart disease prevention (Anthony et al., 1998) cancer prevention, particulary with respect to breast (Peterson and Barnes, 1991 Wu et al., 1996 Messina et al., 1997 Cline and Hughes, 1998), prostate (Griffiths et al., 1998 Stephens, 1999) and colon (Messina and Bennink, 1998) cancers bone mass density increase to prevent osteoporosis (Anderson and Camer, 1997) and reduction of postmenopausal syndromes in women (Knight et al., 1996). 

According to the FDA (Fuller, 1999), DFMs that have been included in food for many years without any adverse effects are GRAS and have been shown to have beneficial effects in the animal (Fuller, 1989 Juven et al, 1991 Lee et al., 1999). The concept of DFMs is now universally accepted, and a substantial amount of research is being directed toward formulation of mixtures of DFM strains that would have potential beneficial effects in the animal, including improvement of animal performance and inhibition of food-borne pathogens. 

Ryu B, Kim SK (2013) Potential beneficial effects of marine Peptide on human neuron health. Curr Protein Pept Sci 14 173-176... 

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