Testosterone replacement therapy

Androderm, anotiier transdermal system, is applied nightly to clean, dry skin on the abdomen, tiiigh, back, or upper arm. This system is not applied to die scrotum. Sites are rotated, witii 7 days between application to any specific site The system is applied immediately after opening the pouch and removing die protective covering. If the patient has not exhibited a therapeutic response after 8 weeks of tiierapy, another form of testosterone replacement therapy should be considered. 

Teriparatide can be used if bisphosphonates are not tolerated or contraindicated. Testosterone replacement therapy should be considered in men, and high-dose hormonal oral contraceptives can be considered for premenopausal women with documented hypogonadism. 

Methyltestosterone Synthetic androgen, longer circulatory half-life than testosterone Replacement therapy for male hypogonadal disorders. Breast cancer in females... 

Rhoden EL, Morgenthaler A. Risks of testosterone-replacement therapy and recommendations for monitoring. N Engl J Med 2004 350 482-92. 

V.b.1.2. Gonadotrophin treatment Men with hypopituitarism normally require only testosterone replacement therapy, but if fertility is needed gonadotrophins are necessary to stimulate spermatogenesis. This therapy is expensive and often requires prolonged administration in order to achieve an adequate sperm count, and its use should be restricted to specialist centres. 

Morelli A, Corona G, Filippi S, Ambrosini S, Forti G, Vignozzi L et al. Which patients with sexual dysfunction are suitable for testosterone replacement therapy . J Endocrinol Invest 2007 30(10) 880-8. 

Testosterone replacement therapy Testosterone Androgel Carbomer 980/sodium hydroxide Hydroalcoholic... 

Nieschlag E, Behre HM, Bouchard P, Corrales JJ, Jones TH, Stalla GK, Webb SM, Wu FCW. Testosterone replacement therapy current trends and future directions. Hum Reprod Update 2004 10 409-19. 

Tan RS, Culberson JW. An integrative review on current evidence of testosterone replacement therapy for the andropause. Maturitas 2003 45 15-27. 

Parker S, Armitage M. Experience with transdermal testosterone replacement therapy for hypogonadal men. Clin Endocrinol (Oxf) 1999 50(l) 57-62. 

Tan RS, Salazar JA. Risks of testosterone replacement therapy in ageing men. Expert Opin Drug Saf. 2004 3 599-606. 

The use of testosterone replacement therapy for the treatment of hypogonadism and ED may assist PDE5 inhibitors if they have failed to be effective (57). Testosterone levels within the normal range have neutral or potentially beneficial effects on the cardiovascular system (58). Androgen replacement therapy should be offered to men with CAD and hypogonadism if symptomatically appropriate. The absence of long-term studies needs to be addressed in terms of possible preventive properties on the vascular wall, reduction in low-density lipoprotein levels, and the reduction of insulin resistance in contrast to the increase in hematocrit and risk of exacerbating prostate cancer. 

Testosterone-replacement therapy, combined with 17/9-estradiol-replacement therapy, has been used in peri- and postmenopausal women and after surgically induced menopause... 

Slowing the release of the parent steroid is a great benefit in steroid medicine, as free testosterone (or other steroid hormones) previously would remain active in the body for a very short period of time (typically hours). This would necessitate an unpleasant daily injection schedule if one wished to maintain a continuous elevation of testosterone (the goal of testosterone replacement therapy). By adding an ester, the patient can visit the doctor as infrequently as once per month for his injection, instead of having to constantly re-administer the drug to achieve a therapeutic effect. Clearly without the use of an ester, therapy with an injectable anabolic/androgen would be much more difficult. 

Velazquez, E. and Bellabarba Arata, G. (1998) Testosterone replacement therapy. Archives of Andrology, 41, 79-90. 

Hellstrom, Wayne J. G. Testosterone Replacement Therapy. Digital Urology Journal. 

Table 45.1. Testosterone Replacement Therapy Benefits Risks...

Hameed A, Brothwood T, Bouloux P. Delivery of testosterone replacement therapy. Current Opinion in Investigational Drugs. October 2003 4(10) 1213-1219. PubMed PMID 14649214. 

Panzer C, Guay A. Testosterone replacement therapy in naturally and surgically menopausal women. J Sex Med 2009 6 8-18. 

Bhattacharya RK, Khera M, BKck G, Kushner H, Miner MM. Testosterone replacement therapy among elderly males the Testim Registry in the US (TRiUS). CKn Interv Aging 2012 7 321-30. 

HRT, Hormone replacement therapy. TRT, Testosterone replacement therapy. 

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