Marine peptide

This oxazole synthesis has been used to prepare some important biologically active compounds such as 3-[2-R-l,3-oxazol-5-yl)indoles (370) (R = Me pimpri-nine R = Et pimprinethine R = Pr WS-30581A] and l-Boc-2-chloro-3-(2-methyl-l,3-oxazol-5-yl)indole, a structural fragment of the cytotoxic marine peptide diazonamide A (371). 

Bioactive Marine Peptides Nutraceutical Value and Novel Approaches... 

Although historically most useful antibiotics have come from spore forming microorganisms, marine organisms have yielded the candidate antitumor peptide dideinnin B and cytostatic peptides such as the patellamides. Many of the marine peptides have little or no antimicrobial... 

Ryu B, Kim SK (2013) Potential beneficial effects of marine Peptide on human neuron health. Curr Protein Pept Sci 14 173-176... 

Although historically most useful antibiotics have come from spore forming microorganisms, marine organisms have yielded the candidate antitumor peptide didemnin B [77327-50-0] (2) and cytostatic peptides such as the patellamides (3). Many of the marine peptides have little or no antimicrobial activity. Antibacterial peptides called magainins are found in frog skin (4) and antibacterial proteins called defensins are found in mammalian white blood cells (5). The commercially important insecticidal proteins from Bacillus thuringensis (6) are not discussed herein nor are the numerous peptide siderophores (7,8), which, except for the albomycins (9), are usually not antimicrobial. 

BAN 14] Banaigs B., Bonnard I., Witczak A. et al, Marine peptides secondary metabolites, in ontstanding marine molecules and new trends in analytical methods , in La Barre S., Kornprobst J.M. (eds). Outstanding... 

Edler, M.C., Eernandez, A.M., Lassota, P., Ireland, C.M., and Barrows, L.R. (2002) Inhibition of tubulin polymerization by vitilevuamide, a bicyclic marine peptide, at a site distinct from colchicine, the vinca alkaloids, and dolastatin 10. Biochem. Pharmacol, 63, 707-715. 

Rocchi, E., Vigo, J., Viallet, P., Bonnard, J., Banaigs, B., and Salmon, J. M. (1999) Multiwavelength videomicrofluorimetric study of cytotoxic properties of a marine peptide, didemnin B, using adriamycin as reference compound. Anticancer Res., 19, 3559-3568. 

Shioiri. T. (1994) Total synthesis of dolastatin 10. An antitumour marine peptide containing unusual amino acids./. Synth. Org. Chem. Jpn, 52, 392-402. 

C.M. (1998) Structural studies of marine peptides. Pure Appl. Chem., 70, 2130-2137. 

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