Toxicology postmortem

Herrin, G., McCurdy, H.H.H. and Wall, W.H. (2005) Investigation of an LCMSMS (QTrap) Method for the Rapid Screening and Identification of Drugs in Postmortem Toxicology Whole Blood Samples. J Anal Toxicol, 29, 599. 

The authors recommended including vitreous glucose and gammahydroxybutyrate analysis as part of postmortem toxicology work-up when the drug screen reveals either olanzapine or clozapine. 

Skopp G (2009) Postmortem toxicology artifacts. In Wiley encyclopedia of forensic science, doi 10.1002/9780470061589.fsa417... 

Another complicating factor in the interpretation of postmortem toxicology results is the phenomenon known as postmortem production. This phenomenon is most applicable to blood alcohol levels after a fatality has occurred. Postmortem production can account for measurable blood ethanol levels after a fatality that may have no connection to prior exposure to alcohol. Postmortem ethanol production can result from a number of sources that include the existence of large numbers of appropriate microorganisms in improperly preserved bodies, or from bodies that suffered severe trauma at death. In any case, the forensic toxicologist attempting to offer an interpretation of these results should carefully consider these facts. 

Drummer OH. Postmortem toxicology of drugs of abuse. Forensic Sci Int 2004 142 101-13. 

Coles, R., M. M. Kushnir, G. J. Nelson, A. Gwendolyn, cuid F. M. Urry. 2007. Simultaneous determination of codeine, morphine, hydrocodone hydromor-phone, oxycodone, and 6-acetylmorphine in urine, serum, plasma, whole blood, and meconium by LC-MS/MS. Journal of Analytical Toxicology 31 (1) 1-14. Drummer, O. H. 2004. Postmortem toxicology of abused drugs. Forensic Science International 142 (2-3) 101-113. 

Drummer, O. H. 2007. Postmortem toxicology. Forensic Science International 165 (2-3) 199-203. 

Jones, A. W. 2009. In press. Postmortem toxicology is not quackery when done by qualified practitioners. Journal of Forensic Science and Legal Medicine. 

Karch, S. B. 2003. Is postmortem toxicology quackery Journal of Clinical and Forensic Medicine 10 (3) 197-198. 

Karch, S. B., ed. 2007. Postmortem toxicology of abused drugs. Boca Raton, FL CRC Press. 

Herrin GL, McCurdy HH, Wall WH. Investigation of an LC-MS-MS (QTrap) method for the rapid screening and identification of drugs in postmortem toxicology whole blood samples. J Anal Toxicol 2005 29 599-606. 

P. columbina, 2886 P. tenera (Pyropia tenera), 2887 Portal vein thrombosis, 1387 Portisins, 1787 Posaconazole, 1277 Postharvest processes, 2318 Post-harvest treatment, 1601 Post-hyperpolarization, 4097 Postmenopausal, 2408, 2419, 3708 Post-menopausal women, 2448 Postmortem toxicology, 1111 Post-traumatic stress disorder (PSTD), 1471 Potassium channels, 41, 2365, 3996 Potentially allergenic substances (PASs), 3293 Potocytosis, 2471 Pour-ons, 4072, 4074, 4076 PPAR. See Peroxisome proliferator-activated receptor (PPAR)... 

Other different sample is vitreous humor, a biological fluid frequently used in postmortem toxicological analysis since all substances present in blood are also present. This matrix is relatively protected from postmortem degradation and contamination and its analysis can provide information in those cases where other biological samples have suffered extensive chemical changes during the postmortem interval. This sample has been analyzed by GC-MS for controlling... 

A 47-year-old woman with schizophrenia was found dead in her apartment. She had been taking lithium and olanzapine. Autopsy showed an acute pulmonary embolus in the left main pulmonary artery, with extension into the lobar branches and an adherent thrombus in the left popliteal vein. There was no evidence of other pathology. Postmortem toxicology confirmed the presence of olanzapine and showed no other substances. There were no other risk factors, such as obesity, a sedentary lifestyle, a history of smoking, recent trauma or immobilization, use of estrogens, or a family history of thrombotic events factor V Leiden and prothrombin mutations were negative. 

Kintz P. Value of hair analysis in postmortem toxicology. Forensic Sd Int 2004 142 127-34. 

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