Polyunsaturated fatty acids biosynthesis

Certik, M. 2000. Fermentation physiology and regulation of microbial polyunsaturated fatty acid biosynthesis. In Mohan, R. M. (Ed.), Research Advances in Bioscience Bioengineering (1, pp. 45-64). Kerala Global Research Network. 

Napier J, Michaelson LV (2001) Genomic and functional characterisation of polyunsaturated fatty acid biosynthesis in Caenorhabditis elegans. Lipids 36 761-766... 

D Andrea, S., Guillou, H., Jan, S., Catheline, D., Thibault, J. N., Bouriel, M., Rioux, V., and Legrand, P. The same rat Delta6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis. Biochem J 364... 

The lignan (+)-sesamin and related lignans present in sesame seeds or its oil are specific inhibitors of A5-desaturase in polyunsaturated fatty acid biosynthesis in both microorganisms and animals [273,274], The results obtained in experiments with both a cell-free extract of the fungus Mortierella alpina and rat liver microsomes demonstrated that (+)-sesamin... 

DuPont scientists were the first to clone FAD2 and FADS genes from the soybean (2). They also provided conclusive evidence for the mechanism of polyunsaturated fatty acid biosynthesis, when antisense or cosuppression of the FAD2 gene led to lower n-6 desaturase activity, and the accumulation of oleic acid in glycerolipids. This was demonstrated not only in soybeans, but also in other oilseed crops, such as canola and sunflower (Table 1). These transgenic events... 

R., Wenzel, S.C. et al. (2014) Polyunsaturated fatty acid biosynthesis in myxobacteria Different PUFA synthases and their product diversity. 

BELL M V, DICK J R, ANDERSON T R and POND D w (2007) Apphcation of liposome and stable isotope tracer techniques to study polyunsaturated fatty acid biosynthesis in marine zooplankton. Journal of Plankton Research 29 417-422. 

His work has been done in the Faculty of Ciencias Exactas at Buenos Aires University. I personally had the pleasure of working in his laboratory and there began in 1946 several studies on lipids. First we studied fish lipids and waxes. Then we started a series of research projects on polyunsaturated fatty acid biosynthesis in different species of the animal kingdom as well as on the lipid metabolism and the effect of diabetes on tumor cells. Our group, the oldest in continuous research in lipid biochemistry, developed in the Catedra de Bioquimica of the Institute de Fisiologia of the Faculty of Medicine of La Plata University. To this group belong... 

It would thus appear that once the rate limiting step in the oleate sequence is bypassed that the type of unsaturated fatty acid found in liver lipids is dictated by specificities for incorporation rather than for regulation at the site of polyunsaturated fatty acid biosynthesis. 

These studies show that in some cases the types of unsaturated fatty acids found in liver lipids are determined primarily by regulation of polyunsaturated fatty acid biosynthesis. In other cases, rates of conversion must be correlated with other controls such as competitive interactions, retroconversion, and specificities for incorporating given acids into lipids in order to explain the types of unsaturated fatty acids found in liver lipids. 

Without discussing the importance of retro-conversion reactions it is obvious that the regulation of A6 desaturase activity would control all polyunsaturated fatty acid biosynthesis due to the key position in the pattern. (Fig. 1). 

Therefore these results compared to the others already mentioned confirm that the A6 desaturation is sensitive to insulin concentration enhancing polyunsaturated fatty acid biosynthesis. 

Shimizu, S., Akimoto, K., Shinmen, Y., Kawashima, H., Sugano, M. and Yamada, H. (1991) Seasmin is a potent and specific inhibitor of A5-desaturase in polyunsaturated fatty acid biosynthesis. Lipids 26, 512-516. 

Domeigue, F, Abbadi A, Ott C, Zank, T. K. Zahringer U, Heinz E acyl carriers used as substrates by the desaturases and elongasses involved in very long-chain polyunsaturated fatty acids biosynthesis reconstituted in yeast. J Biol Chem 2003, 278 35115-35126. 

I A GENERAL FRAME FOR THE STUDY OF POLYUNSATURATED FATTY ACID BIOSYNTHESIS IN PLANTS THE PROKARYOTIC AND EUKARYOTIC PATHWAYS [3-7 ]. 

Green, A.G. (1986) Genetic control of polyunsaturated fatty acid biosynthesis in flax (linum usitatissimum) seed o]].lheor. Appl. Genet. 72, 654-661. 

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