Polymorphous light eruption

Psoralens, or furocoumarins, are a class of heterocyclic aromatic compounds used in photochemotherapy treatment of a variety of skin diseases such as psoriasis, vitiligo, mycosis fungoides, polymorphous light eruption, and more [68-71]. The compounds are present in numerous plants throughout the world. In photoche-... 

Both topical and systemic PUVA are useful in some patients with vitiligo, although repigmentation is rarely complete. Other skin diseases for which PUVA may be helpful include atopic dermatitis, dyshidrotic eczema, and polymorphous light eruption. 

Hydroxychloroquine is approved for the treatment of both systemic and cutaneous lupus erythematosus. Both chloroquine and quinacrine (Atabrine) are also effective in this skin disease. Low-dose chloroquine is used for the therapy of porphyria cutanea tarda in patients in whom phlebotomy has failed or is contraindicated. Other skin diseases in which the drugs are useful (after sunscreens and avoidance of sun exposure) include polymorphous light eruption and solar urticaria. 

Atopic dermatitis, contact dermatitis, dermatitis, discoid lupus erythematosus, eczema, exfoliative dermatitis, granuloma annulare, lichen planus, lichen simplex, polymorphous light eruption, pruritus, psoriasis, Rhus dermatitis, seborrheic dermatitis, xerosis ... 

Unlabeled Uses Polymorphous light eruption, psoriasis, sunlight sensitivity... 

Rhodes, L.E., Durham, B.H., Fraser, W.D., and Friedmann, P.S., Dietary fish oil reduces basal and ultraviolet B-generated PGE2 levels in skin and increases the threshold to provocation of polymorphic light eruption, J. Invest. Dermatol., 105, 532, 1995. 

Uses. Sun screens are no substitute for light-impermeable clothing and sun avoidance. They are, however, beneficial in protecting those who are photosensitive due to drugs (below) or to disease, i.e. for photodermatoses such as photosensitivity dermatitis, polymorphic light eruption, cutaneous porphyrias and lupus erythematosus. Methodical use of sunscreens appears to reduce the incidence of squamous cell carcinoma in vulnerable individuals. 

Systemic protection, as opposed to application of drug to exposed areas, should be considered when the topical measures fail. Antimalarials such as hydroxychloroquine may be effective for short periods in polymorphic light eruption and in cutaneous lupus erythematosus. 

Nephrotic syndrome has been reported in a patient treated with PUVA for polymorphic light eruption (SEDA-9,132). 

Exacerbation of polymorphic light eruption Generalized exanthematous pustulosis (SEDA-20, 153) Granuloma annulare (SEDA-4, 105)... 

A 36-year-old woman had been treated for a polymorphic light eruption with two annual courses of PUVA, three times weekly for 6 weeks, plus oral 5-methoxypsoralen 60 mg, without any adverse effects. However, during the fourth course, 30 minutes after... 

PUVA is used most commonly in the treatment of psoriasis, vitiligo, and cutaneous T-cell lymphoma. However, up to 30 other skin diseases have been reported to be responsive to PUVA therapy. The most common of these include palmarplantar pustulosis, polymorphous light eruption, dishydrotic eczema, atopic dermatitis, allergic contact dermatitis, actinic reticuloid, solar urticaria, pityriasis lichenoides, and graft versus host disease. 

El 60(a) Solatene ) is a carotenoid and a vitamin substance widespread in plants and animals. In plants it is almost always associated with chlorophyll. It is a vitamin A precursor and exhibits strong vitamin A activity. It can be used in topical ultraviolet sunscreen preparations (but has not been shown to be effective). It can be given orally to reduce photosensitivity reactions in patients with erythro-poetic protoporphyria, and is sometimes tried as an adjunct in treating polymorphous light eruptions. It can be used orally as a dietary supplement also used as a yellow food colorant. 

Indications Erythropoetic protoporphyria, Polymorphous light eruption, Photodamage... 

THERAPEUTIC USES FDA-approved dermatological uses of hydroxychloroquine include treatment of discoid and systemic lupus erythematosus. Unapproved but first-line uses include treatment of dermatomyositis, porphyria cutanea tarda, polymorphous light eruption, sarcoidosis, eosinophilic fasciitis, lymphocytic infiltrate of Jessner, lymphocytoma cutis, solar urticaria, granuloma annulare, and some forms of panniculitis. 

Many skin diseases can be induced or worsened by UVR. Among the idiopathic photodermatoses, polymorphic light eruption with delayed reactions to sun exposure (which it is nevertheless correlated to) is the most frequent. Phototoxic or photoallergic dermatitis is more frequent and is due to contact with substances that, by an irritant or immunological mechanism, can... 

Finally, it is important to know the influence that the quantity of sxmscreen applied may have and its ability to protect against UV-induced polymorphous light eruption (PLE). Despite the fact tixat most people apply less sxmscreen than the 2 mg/cm required to measure sun protection factor (SPF), there is a lack of clinical data on the protection afforded from lower applied quantities. The current study compares the ability of sxmscreens to protect against UV-induced PLE when applied at 2 and 1 mg/cm [83" ]. 

Bissonnette R, Nigen S, Bolduc C. Influence of the quantity of simscreen applied on the ability to protect against ultraviolet-induced polymorphous light eruption. Photoderm Photoimm Photomed 2012 28(5) 240-3. 

Polymorphous light eruption Hydroa vacciniforme Solar urticaria Persistent light reaction... 

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