Drug delivery polymeric biomaterials

Fu J, Fiegel J, Krauland E, and Hanes J. New polymeric carriers for controlled drug delivery following inhalation or injection [J]. Biomaterials, 2002, 23, 4425 1433. 

Shih, C., Higuchi, T., and Himmelstein, K. J., Drug delivery from catalyzed erodible polymeric matrices of poly(ortho esters). Biomaterials. 5, 237-240, 1984. 

Surya K. Mallapragada and Jennifer B. Recknor, Polymeric Biomaterias for Nerve Regeneration Anthony M. Lowman, Thomas D. Dziubla, Petr Bures, and Nicholas A. Peppas, Structural and Dynamic Response of Neutral and Intelligent Networks in Biomedical Environments F. Kurds Kasper and Antonios G. Mikos, Biomaterials and Gene Therapy Balaji Narasimhan and Matt J. Kipper, Surface-Erodihle Biomaterials for Drug Delivery... 

Fitzgerald, P., and Wilson, C. G. (1994), Polymeric systems for ophthalmic drug delivery, in Dimitriuitra S., Ed., Polymeric Biomaterials, Marcel Dekker, New York, pp. 373-398. 

Block copolymers containing acrylate termini, (I), were prepared by Cellesi [1], and they were subjected to either a Michael-type addition or were photo-polymerized and used as drug delivery agents or biomaterials. 

This article describes macrophage phagocytosis of polymer microspheres for the purpose of a deeper understanding of the polymer interaction with phagocytic cells. The provided information should contribute to the development of polymeric biomaterials, especially of polymer carriers applicable for drug delivery systems. 

Hyaluronan is the most common negatively charged glycosaminoglycan in the human vitreous humor, and is known to interact with polymeric and liposomal DNA complexes, where hyaluronan solutions have been shown to decrease the cellular uptake of complexes.This is useful for enhancing the availability and retention time of drugs administered to the eye. It is immunoneutral, which makes it useful for the attachment of biomaterials for use in tissue engineering and drug delivery... 

Polymeric hydrogels have been attractive biomaterials for drug delivery, particularly for controlled release of delicate bioactive agents such as proteins and peptides. However, chemically crosslinked hydrogels can be applied only as implantables,... 

Nair, L.S. and Laurencin, C.T. (2006) Polymeric applications as biomaterials in the areas of tissue engineering and controlled drug delivery. Adv. Biochem. Engng/Biotechnol. Spec. Issue, Tissue Eng., 102, 47 -90. 

Figure 1.1 Development of polymeric biomaterials for controlled delivery tissues. This book will consider several aspects of the development of delivery systems including the characterization of biocompatible polymers, methods for incorporating bioactive agents into polymer matrices and microspheres, and methods for quantitative analysis of kinetics of drug release. Since these devices are developed for the delivery of agents to tissues, a critical component in this analysis will be the consideration of drug transport through the local tissue surrounding the implant.

The sections that follow provide a schematic overview of the polymeric materials most used in drug delivery systems. For more details, readers are referred to other recent books for aspects of biomaterials that are not covered in detail here. For example, biocompatibility and interactions with implanted polymers are reviewed in several edited volumes [2, 13, 14]. 

Among the many classes of polymeric materials now available for use as biomaterials, non-degradable, hydrophobic polymers are the most widely used. Silicone, polyethylene, polyurethanes, PMMA, and EVAc account for the majority of polymeric materials currently used in clinical applications. Consider, for example, the medical applications listed in Table A.l most of these applications require a polymer that does not change substantially during the period of use. This chapter describes some of the most commonly used non-degradable polymers that are used as biomaterials, with an emphasis on their use in drug delivery systems. 

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