Polylysines

Leokband D et al 1993 Measurements of oonformational ohanges during adhesion of lipid and protein (polylysine and S-layer) surfaoes Biotech. Bloeng. 42 167-77... 

Figure C 1.5.6. Single Ag nanoparticles imaged with evanescent-wave excitation. (A) Unfiltered photograph showing scattered laser light (514.5 nm) from Ag particles immobilized on a polylysine-coated surface. (B) Bandpass filtered (540-580 nm) photograph taken from a blank Ag colloid sample incubated witli 1 mM NaCl and...

Macromolecules bearing reactive groups in the repeat units along their chains are capable of multiple interaction with the matrix. As early as 1973, Wilchek prepared Sepharose-based supports chemically modified by chemisorbed polylysine and polyvinylamine [41]. The leakage of dyes covalently bonded to these supports was reduced remarkably as compared to non-modified Sepharose activated by cyanogen bromide. Thus, stable and high capacity affinity adsorbents could be prepared by the introduction of macromolecular spacers between a matrix and a biospecific ligand. 

Poly(3,3 ionene) 80 Polylysine 148 Polymethacrylic acid 54 Polypeptides 147 Polypropylene oxide 158 Polysoaps 63... 

Figure 4. Neurite outgrowth by LA-N-1 human neuroblastoma cells in culture. LA-N-1 human PNS neuroblastoma cells were grown for five days in N2 medium (as described by Bottenstein and Sato, 1979) on a polylysine and fibronectin-modified surface. The cells were plated in clumps, rather than as a single cell suspension, which enhances neurite extension. Very long processes result, and exhibit varicosities along their length. Most of the cells have migrated from the central clump. (Photo courtesy of Dr. jane Bottenstein.)...

On the whole, curing procedures appear a promising way to obtain very stable polymer films. Thus, the structure of already mentioned polylysine has been revised as a block polymer involving either the a or e amino groups of lysine Vitamin Bj2 modified carbon electrodes were prepared by thermal curing of a mixture of a diamino functionalized derivative 5 and an epoxy prepolymer 6 of the araldite... 

Yu M, Nowak AP, Deming TJ, Pochan DJ (1999) Methylated mono- and diethyleneglycol functionalized polylysines nonionic, alpha-helical, water-soluble polypeptides. J Am Chem Soc 121 12210-12211... 

Peptides have been used for the delivery of gene-based drugs. Several rationales have been utilized. Cationic peptides are used to neutralize the charges of DNA or oligonucleotide. These peptides include polylysines and polyarginines [241,244,245]. They form complexes with DNA or oligonucleotide, thereby resulting in enhanced cellular uptake. 

Smith and co-workers (194) have used this chemistry to prepare carboxyl-modified Si(lll) surfaces at which polylysine-tethered DNA is electrostatically adsorbed (Fig. 60). An alternative approach involved covalent attachment of a pre-synthesized oligonucleotide bearing a terminal carboxyl group to an amine-modified Si(001) surface (195). 

Other polypeptides obtained by polycondensation with phosphorous diester triazolides are N6-Z-polylysine,[28] Na-Z-isopolylysine,t281 and the sequence polypeptides from /J-Ala-/J-Ala-Gly.l53]... 

Fig. 3i-iii. Dendrimer synthesis using branched building blocks i Denkewalter s polylysine dendrimers ii Newkome s polyamide dendrimers iii Frechet s aryl ether dendrimers... 

Fig. 7. Doubly-branching polylysine dendra functionalized with a chloroalkyl group and with various glycosides [33-39]...

Potential applications of vitamin Bi2 in electrocatalytic degradation of dibromide and a-haloacetic acid pollutants has been demonstrated in aqueous buffers303,304 and in surfactant-stabilized emulsions.305 Electroreductive dehalogenations in water and microemulsions were also efficiently catalyzed by a vitamin Bi2 derivative grafted onto a polylysine-coated electrode.306... 

This method represents one of the first attempts towards macromolecular agents.121-123 As many as 60-90 [Gd(DTPA)]2- or [Gd(DOTA)] chelates were first linked to a polylysine chain, then covalently conjugated to a HSA molecule.124 The increase in relaxivity per Gd, as compared with the monomeric chelate, was remarkable (two- to threefold), though far from optimal. However, the development of these albumin conjugates was abandoned at an early stage, since their synthesis is not easily controlled, and there are also toxicity concerns due to the retention of gadolinium observed in the bones and liver.125... 

Au-nanopartide nanowires based on DNA and polylysine templates. Angewandte Chemie-International Edition, 41, 2323-2327. 

Since both are negatively charged, a first coating of the capsules surface with L-polylysine is needed. 

S. Hana, H. Baigude, K. Hattori, T. Yoshida, and T. Uryu, Synthesis of new spherical and hemispherical oligosaccharides with polylysine core scaffold, Carbohydr. Polym., 68 (2007) 26-34. 

E. A. B. Kantchev, C.-C. Chang, and D.-K. Chang, Direct Fmoc/tert-Bu solid phase synthesis of octamannosyl polylysine dendrimer-peptide conjugates, Biopolymers, 84 (2006) 232-240. 

Wagner E, Ogris M, Zauner W (1998) Polylysine-based transfection systems utilizing receptor-mediated delivery. Adv Drug Deliv Rev 30 97-113... 

Zauner W, Kichler A, Schmidt W, Sinski A, Wagner E (1996) Glycerol enhancement of ligand-polylysine/DNA transfection. Biotechniques 20 905-913... 

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