Polylysine Dendrons

Figure 11.19 (a) Structure of a hydrophilic fifth-generation poly(propylene imine) dendron containing a focal hydrophobic polystyrene block, (b) Structure of a fourth-generation r-buty-loxycarbonyl (Boc)-protected polylysine dendron having a focal poly(ethylene glycol) chain. 

Many variations of K2K dendrons have also evolved. A symmetrical version with a p-alanine spacer 39 at the a-amine of Lys provides a core unit that has symmetrical branching. To limit the flexibility of the branched lysyl template, ornithine, the lower homologue of Lys, as well as more constrained diamino acids 23-25 have been used. 39 62,64 Nonbranched polylysine dendrons 26 that are linear, and helical 71 and cyclic peptides 27 have also been developed to impart different forms of dendrimeric architecture (Scheme 5). 

Scheme 15.4. Synthesis of polylysine dendrons on solid support.

Figure 15.2. Various types of conjugates generated on solid support with polylysine dendrons.

Figure 15.7. Cationic lipidic polylysine dendrons prepared by Florence et al.

Laurino P, Kikkeri R, Azzouz N, Seeberger PH (2011) Detection of bacteria using glyco-dendronized polylysine prepared by continuous flow photopolymerization. Nano Lett 11 (l) 73-78. doi 10.1021/nll02821f... 

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