Poly PAMAM

Poly(PAMAM), starburst dendrimer Starburst 2nd generation 93376-66-0 4.7,11.14,18,21,25,28,32,35-Decaazaoctatriacontane-diamide, etc R C 42H28gN5802 ... 

Fig. 2. Poly(amidoamine) (PAMAM) dendrimers with carboxylate groups at the external surface...

Anionic poly(amidoamine) (PAMAM) dendrimer was selected as a model of the soluble acidic-rich proteins to prepare CaC03 film on a poly(ethylenimine) film [49]. The CaCOj/polylethylenimine) composite film was obtained in the... 

The synthesis and structure of a dendrimer can be illustrated by the well-known poly (amidoamine) type (called PAMAM), which describes the monomers making up the complete polymer. The synthesis starts from a core diamine (or ammonia) molecule. The diamine can be of various lengths and spacer arm properties and even contain cleavable components. Typically, the core... 

Huang, B., and Tomalia, D.A. (2005) Dendronization of gold and CdSe/cdS (core-shell) quantum dots with tomalia type, thiol core, functionalized poly(amidoamine) (PAMAM) dendrons. J. Lumin. Ill, 215-223. 

The team of Crooks is involved in the synthesis and the use of dendrimers and, more particularly, poly(amidoamine) dendrimers (PAMAM), for the preparation of dendrimer-encapsulated mono- or bimetallic nanoparticles of various metals (Pt, Pd, Cu, Au, Ag, Ni, etc.) [55, 56]. The dendrimers were used as nanocatalysts for the hydrogenation of allyl alcohol and N-isopropylacrylamide or other alkenes under different reaction conditions (water, organic solvents, biphasic fluorous/or-ganic solvents or supercritical COz). The hydrogenation reaction rate is dependent on dendrimer generation, as higher-generation dendrimers are more sterically... 

Poly(propyleneimine) dendrimers are sold by the company DSM, Netherlands, under the name of Astramol . Poly(amidoamine) dendrimers are available as PAMAM dendrimers at Aldrich. 

Dendrons and dendrimers are the most intensely investigated subset of dendritic polymers. In the past decade over 2000 literature references have appeared on this unique class of structure controlled polymers. The term dendrimer was coined by Tomalia, et al. over 15 years ago in the first reports on poly(amidoamine) (PAMAM) dendrimers [75, 76]. It is derived from the Greek words dendri-(branch tree-like) and meros - part of). Poly(amidoamine) dendrimers constitute the first dendrimer family to be commercialized and undoubtedly represent the most extensively characterized and best understood series at this time. In view of the extensive literature information in this area, much of the remaining overview will focus on PAMAM dendrimers and will... 

Figure 1.14 Three-dimensional projection of dendrimer core-shell architecture for G = 4.5 poly(amidomine) (PAMAM) dendrimer with principal architectural components (I) core, (II) interior and (III) surface...

Figure 1.21 Periodic properties for poly(amidoamine) (PAMAM) dendrimers as a function of generation G = 0-10 (I) flexible scaffolding (G = 0-3) (II) container properties (G = 4-6) and (III) rigid surface scaffolding (G = 7-10) various chemo/ physical dendrimer surfaces amplified according to Z = NCN where Nc = core multiplicity, Nb = branch cell multiplicity, G = generation...

Figure 1.22 A comparison of dimensional length scales (A) for poly(amido-amine) (PAMAM) dendrimers Nc = 3, Nb = 2 (NH3 core) and various biological entities (e.g. proteins, DNA and lipid bilayers)...

Gel electrophoresis is widely used in the routine analysis and separation of many well-known biopolymers such as proteins or nucleic acids. Little has been reported concerning the use of this methodology for the analysis of synthetic polymers, undoubtedly since in many cases these polymers are not soluble in aqueous solution - a medium normally used for electrophoresis. Even for those water-soluble synthetic polymers, the broad molecular weight dispersities usually associated with traditional polymers generally preclude the use of electrophoretic methods. Dendrimers, however, especially those constructed using semi-controlled or controlled structure synthesis (Chapters 8 and 9), possess narrow molecular weight distribution and those that are sufficiently water solubile, usually are ideal analytes for electrophoretic methods. More specifically, poly(amidoamine) (PAMAM) and related dendrimers have been proven amendable to gel electrophoresis, as will be discussed in this chapter. 

Electrophoresis is normally run in aqueous media, hence the analytes must be soluble in water. Presently only three types of water-soluble dendrimers have been successfully analyzed using gel electrophoresis techniques. The list includes Starburst PAMAM dendrimers [21], nucleic acid dendrimers [21] and poly(lysine) dendrimers [23, 24] (see Figures 10.2, 10.4 and 10.6). However, in each case appropriate water solubilizing terminal groups are required (i.e. -NH2, -OH or C02H groups) for suitable electrophoretic analysis. 

Figure 10.3 Electrophoretogram of several generations of (EDA-core) PAMAM dendrimers (E 0-10). The unlabeled smear in the middle of the gel is a conventional polydispersed linear poly(lysine) sample as a comparison...

At the center of the dendrimer is the core that represents the first synthetic step in divergent synthesis, or the last step in convergent synthesis. Each concentric shell of branched units is a generation (X), designated (GX), of identical repeat units. Hundreds of chemical repeat units have been reported [3, 4], but our characterization has been focused primarily on poly(amidoamine) (PAMAM), -(CH2CH2CONHCH2CH2N) < [1], or poly(propyleneimine)... 

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