Dendrimer, poly PAMAM

Roberts, J., Bhalgat, M. and Zera, R. T. (1996) Preliminary evaluation of poly-amidoamine (PAMAM) starburst dendrimers. J. Biomedical. Materials Res., 30, 53 (1996). 

PEI, Poly(ethylene imine) [17] PAMAM, Poly(amidoamine) dendrimer [18]... 

Tomalia-type poly(amidoamine) (PAMAM) dendrimers and their use as precise, fundamental building blocks to form poly(dendrimers) or so-called starburst polymers. These poly(dendrimers) are now referred to as megamers [35,36] and are described in more detail later. Other pioneers in the dendritic polymer field include Vogtle, New-kome, Frechet, and others. These historical contributions have been reviewed recently [33],... 

Starburst dendrimers have received considerable attention in the area of heterogeneous catalyst synthesis in the last decade. Although Tomalia et al. and Bosman et al. originally discovered these hyperbranched macromolecules and their host-guest properties in the mid-1980s. Crooks and coworkers were the first to demonstrate the ability of poly(amidoamine) (PAMAM) starburst dendrimers to act as metal nanoparticle stabilizers that could potentially aid in the synthesis of supported metal catalysts. The benchmark work of Crooks et al. and subsequent literature reports have underscored the advantages of successfully utilizing PAMAM dendrimer-nanocomposite precursors over conventional catalyst preparation methods. 

FIGURE 9.1 Structure of a 2nd generation amine-terminated (G2NH2) poly(amidoamine) (PAMAM) starburst dendrimer. (Courtesy of Dendritech, Inc., http //www.den-dritech.com/pamam.html.)... 

Figure 13.4 shows some specific dendrimer examples. Very early examples of this "cascade synthesis" approach were reported by Vogtle. Here we show two especially well characterized systems. The first has been termed PAMAM [poly(amido amine)]. The second structure, the poly(propylene imine), has been especially well optimized and characterized. Both systems are now available commercially and are produced on the tens of kilogram scale. Many variations of the structures in Figure 13.4 can be obtained by starting with a different core or choosing different reagents. 

More recently, non-traditional polymerization strategies have evolved to produce a fourth new major polymer architecmral class, now referred to as dendritic polymers [43]. This new architectural polymer class consists of four major subsets (1) random hyperbranched, (2) dendrigrafts, (3) dendrons and (4) dendrimers. Dendrimers, the most extensively studied subset were discovered by the Tomalia group while in The Dow Chemical Company laboratories (1979) and represent the first example of synthetic, macromolecular dendritic architecture [43,44]. First use of the term dendrimer appeared in preprints for the first SPSJ International Polymer Conference, held in Kyoto, Japan in 1984 [45]. The following year, a full article in Polymer Journal [46] (Fig. 8) described the first preparation of a complete family of Tomalia-type poly(amidoamine) (PAMAM) dendrimers (G = 1-7) and their use as precise, fundamental building blocks to form poly (dendrimers) or so-called starburst polymers. These poly(dendrimers) are now referred to as megamers [47, 48] and are described in more detail later in Sect. 6.4.3. Other pioneers in the dendritic polymer field include Vogtle, Newkome, Frechet, Majoral, and others. These historical contributions have been reviewed recently [52]. ... 

PAMAM, Poly-L-Lysine and Pentaerythritol-Based Dendrimers.721... 

Two components are needed to construct a dendrimer a multifunctional core and an ABx monomer unit around which to build up the structure. The most commonly used types are polyamidoamine dendrimers (PAMAM), poly 2,2-bis(methylol)propionic acid (PBisMPA) dendrimers, polybenzyl ether dendrimers (PBzE), polymelamine (triazine) dendrimers, polypropyleneimine dendrimers (PPI), and polylysine dendrimers (PEL). PAMAM, PPI and PBisMPA are commercially available. PAMAM (left), PBisMPA (middle) and PPI (right) in Figure 2.7 are the most commonly employed structures in therapeutic applications these have been well characterised both in vitro and in vivo, and their toxicological properties have been evaluated. 

Poly(PAMAM), starburst dendrimer Starburst 2nd generation 93376-66-0 4.7,11.14,18,21,25,28,32,35-Decaazaoctatriacontane-diamide, etc R C 42H28gN5802 ... 

Fig. 2. Poly(amidoamine) (PAMAM) dendrimers with carboxylate groups at the external surface...

Anionic poly(amidoamine) (PAMAM) dendrimer was selected as a model of the soluble acidic-rich proteins to prepare CaC03 film on a poly(ethylenimine) film [49]. The CaCOj/polylethylenimine) composite film was obtained in the... 

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