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Glycodendrimer PAMAM poly

GLYCODENDRIMERS BASED ON POLY(AMIDOAMINES) (PAMAM) DENDRIMERS... [Pg.368]

Figure 13.10 Synthesis of mannose-/glucose-functionalized dendrimers. For dendrimer loading, x + y = 50% loading was used because optimal activity for glycodendrimers with concanavalin A was previously determined to occur at 50% functionalization. Remaining amines from the poly(amido amine) (PAMAM) substrate were capped as alcohols. Figure 13.10 Synthesis of mannose-/glucose-functionalized dendrimers. For dendrimer loading, x + y = 50% loading was used because optimal activity for glycodendrimers with concanavalin A was previously determined to occur at 50% functionalization. Remaining amines from the poly(amido amine) (PAMAM) substrate were capped as alcohols.
Glycodendrimers can be synthesized by both convergent and divergent strategies. Ideally, they can be simply prepared by conjugation of active carbohydrate derivatives onto preformed dendrimers (Scheme 11). Given the commercial availability of poly(amidoamine) (PAMAM, 56) and poly(propyleneimine) (Dab, 57) dendrimers, these amine-ending dendrimers are the most heavily exploited. [Pg.294]

See other pages where Glycodendrimer PAMAM poly is mentioned: [Pg.326]    [Pg.325]    [Pg.328]    [Pg.368]    [Pg.254]    [Pg.254]    [Pg.298]    [Pg.50]    [Pg.104]    [Pg.2626]   
See also in sourсe #XX -- [ Pg.286 ]



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