Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Polar conjugates

After exerting their action in the organism, natural and synthetic hormones are catabolized in the liver by conjugation to glucuronide and/or sulfate moieties, forming more polar conjugated forms which are excreted via urine. This is the main route of hormone excretion in humans and pigs. A fraction of hormones is also excreted in a free form via feces in animals such as sheep and cattle this is the main route for hormone excretion (Table 3) [66, 67],... [Pg.83]

Based on the fundamental dipole moment concepts of mesomeric moment and interaction moment, models to explain the enhanced optical nonlinearities of polarized conjugated molecules have been devised. The equivalent internal field (EIF) model of Oudar and Chemla relates the j8 of a molecule to an equivalent electric field ER due to substituent R which biases the hyperpolarizabilities (28). In the case of donor-acceptor systems anomalously large nonlinearities result as a consequence of contributions from intramolecular charge-transfer interaction (related to /xjnt) and expressions to quantify this contribution have been obtained (29). Related treatments dealing with this problem have appeared one due to Levine and Bethea bearing directly on the EIF model (30), another due to Levine using spectroscopically derived substituent perturbations rather than dipole moment based data (31.) and yet another more empirical treatment by Dulcic and Sauteret involving reinforcement of substituent effects (32). [Pg.64]

Fish and Ecosystem Studies. When bluegill sunfish are exposed to a constant level of methoprene in a dynamic flowthrough system, they accumulate radiocarbon until a plateau is reached after 7-14 days (33). While levels of methoprene in fish were about lOOOx that in water at the plateau, treated bluegill placed into uncontaminated water showed a 93-95% radiocarbon reduction in 14-21 days. Analysis of fish tissues at plateau levels revealed that 90% of the radiocarbon was unmetabolized parent, 1% was the hydroxy ester, while the remainder was polar conjugates. [Pg.173]

Hill M, Parizek A, Bicikova M, Havlikova H, Klak J, et al. 2000. Neuroactive steroids, their precursors, and polar conjugates during parturition and postpartum in maternal and umbilical blood 1. identification and simultaneous determination of pregnanolone isomers. J Steroid Biochem Mol Biol 75 237-244. [Pg.190]

Carbon-Carbon Bond-Forming Reactions TABLE 9.30. POLAR CONJUGATE ADDITION REACTION ... [Pg.569]

P, which usually entails a large, unsymmetrically polarized, conjugated Tt-electron system. Second, the molecules must be arranged in a noncentrosymmetric orientation, which allows a nonzero bulk hyperpolarizability, %(. ... [Pg.282]

Method Donor substituents usually contain heteroatoms whose lone pairs can be modeled in Hiickel calculations by doubly occupied orbitals. To a first approximation, acceptor substituents (polar conjugating groups such as C=0, C=N, NOz) can be represented by a low-lying vacant orbital (jtco for C=0,7tCN for C=N, etc.). In cases where a more realistic model is required, the occupied (nco, 7tCN, etc.) orbitals are added to the calculation. [Pg.84]

Animals. The principal route of elimination is feces most of the radioactivity is excreted within the first 48 hr. Metabolized rapidly to less-toxic metabolites and to polar conjugates. [Pg.1916]

Conjugation of lipophilic xenobiotics to polar cellular constituents renders the xenobiotic more water-soluble. While the lipophilic parent xenobiotics could readily diffuse into the cells, the increase in polarity associated with conjugation greatly reduces the ability of the compound to diffuse across the lipid bilayer of the cell membrane thus trapping the compound within the cell. The polar conjugates must therefore rely upon active transport processes to facilitate efflux from the cell. Hepatocytes, as well as other cells involved in chemical detoxification, are rich with members of the ATP-binding cassette superfamily of active transport proteins (ABC transporters). Cellular efflux of xenobiotics by these transporters is often referred to as Phase III elimination because Phase I or II detoxification processes often precede and are a requirement of Phase III elimination. A detailed description and discussion of elimination and transporters is presented in Chapter 15. [Pg.236]

Extraction of free phytosterols and steryl conjugates In principle, sterols are extracted with common organic solvents like hexane, heptane, methanol, and chloroform, but the more polar conjugates (SFs, SGs, and ASGs) require more polar extraction solvents to be quantitatively extracted from plant sample materials. Therefore, if only selected class(s) of steryl conjugates with similar polarity are analyzed, one solvent extraction can be sufficient. However, for a total lipid extraction for a later fractionation to the individual classes of phytosterol conjugates, one must utilize combinations of extraction solvents to ensure maximum recovery. [Pg.330]

AU considered condensation reactions have some anomalies for the a,j8-unsaturated carbonyl compounds. Most reagents with active hydrogen atoms can react not only with carbonyl groups but also with polarized conjugated double bonds C = C. As a result of this regularity, three products, instead of the estimated one target derivative, are formed in the reactions of a,)8-unsaturated carbonyl compounds with O-alkyl hydroxylamines ... [Pg.502]

LC/MS and LC/MS/MS spectra were acquired on a triple quadrupole mass spectrometer (TSQ-45, Finnigan MAT) using a conventional Finnigan thermospray ion source. No electron filament or discharge electrode was employed. In general, ion source conditions for the polar conjugate metabolites were block temperature 200°-250°C vaporizer... [Pg.126]

Some drugs are metabolized at particular positions in their skeleton. For example, the oral contraceptive megestrol acetate is oxidized at position 6 to give a hydroxyl group at that position. The introduction of a polar group such as this usually allows the formation of polar conjugates which can be quickly eliminated from the system. [Pg.117]

The extraction of polar conjugates from solid samples (e.g. plant material, animal tissue, and feces) is most commonly carried out... [Pg.109]


See other pages where Polar conjugates is mentioned: [Pg.237]    [Pg.63]    [Pg.86]    [Pg.42]    [Pg.144]    [Pg.62]    [Pg.40]    [Pg.144]    [Pg.163]    [Pg.214]    [Pg.151]    [Pg.692]    [Pg.19]    [Pg.218]    [Pg.77]    [Pg.188]    [Pg.158]    [Pg.302]    [Pg.346]    [Pg.397]    [Pg.170]    [Pg.118]    [Pg.274]    [Pg.210]    [Pg.212]    [Pg.212]    [Pg.55]    [Pg.385]    [Pg.272]    [Pg.273]    [Pg.4]    [Pg.19]    [Pg.24]    [Pg.36]    [Pg.385]    [Pg.16]    [Pg.85]   


SEARCH



© 2024 chempedia.info