Podophyllum peltatum mayapple

Podophyllum Antimitotic for venereal warts Podophyllum peltatum Mayapple... 

N Amoican mayapple. Podophyllum peltatum L., Berbaidaceae, Ang. poisonous agait once used by die American Indians to commit suicide... 

Two compounds, VP-16 (etoposide) and a related drug, VM-26 (teniposide), are semisynthetic derivatives of podophyllotoxin, which is extracted from the mayapple root (Podophyllum peltatum). Both an intravenous and an oral formulation of etoposide are approved for clinical use in the USA. 

The resin product obtained by extraction of the dried roots and rhizomes of the North American plant Podophyllum peltatum L. (the American mandrake or mayapple) and of the related Indian species Podophyllum emodi Wall. Ex Royle is known as podophyllin and has long been known to possess medicinal properties. The major active substance in podophyllin is the lignan lactone podophyllotoxin (7) although a variety of other lignans and lignan glycosides have also been isolated from podophyllin. ... 

The terms mandrake and mayapple are used synonymously in the United States, being the plant species Podophyllum peltatum [of the plant family Podophyllaceae], which contains the toxic agent podophyUotoxin, which apparently has an anticancer or cancerostatic action [Hoffman, 1999, p. 81]. However, in Europe the mandrake is the species Mandragora officinarum of the family Solanaceae and contains belladonna-type alkaloids, namely, tropane or atropine alkaloids that include scopolamine and hyoscyamine. These are noted to have an anticancer action [Hoffman, 1991, p. 144]). 

The epipodophyllotoxins (Fig. 42.38) are semisynthetic glycosidic derivatives of podophyllotoxin, the major component of the resinous podophyllin isolated from the dried roots of the American mandrake or mayapple plant (Podophyllum peltatum). Although these compounds are capable of binding to tubulin and inhibiting mitosis, their primary mechanism of antineoplastic action is poisioning topoisomerase II, a mechanism that they share... 

Mayapple Podophyllum peltatum 1,3 Oil is keratolytic. Irritant hypotension, seizures repotted... 

Lignans from the mayapple Podophyllum peltatum) show potent antiviral activity in vivo (MacRae et al. 1989). 

The genus Podophyllum (Berberidaceae family), including the American P. peltatum L. (American mayapple) and Indian or Tibetan P. emodi WaU (syn. P. hexandrum Royle), has been... 

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