Lignan glycosides

Hon C-C, Fin S-J, Cheng J-T, Hsu F-L. (2003) Antidiabetic dimeric guiano-lides and a lignan glycoside from Lactuca indica. J Nat Prod 66 625-629. 

Kuryama, K., and T. Murui. Manufac- S1065 ture of lignan glycosides and lignans... 

Calis, I. et al., Flavonoid, iridoid and lignan glycosides from Putoria calabrica, J. Nat. Prod., 64, 961, 2001. 

Ciliatoside A (lignan glycoside) Ciliatoside B (lignan glycoside) Coelonin (phenolic)... 

In the same way that the toxic properties of the constituents of the yew tree have encouraged investigation of all its parts, practically all Taxus species have also been studied T. baccata L. in Europe, T. brevifolia in North America, T. cuspidata, T. wallichiana, and T. mairei in Asia, and Austrotaxus spiccata Compton in New Caledonia. Although taxanes may be considered as the typical constituents of the genus Taxus, other natural products, such as ecdysones, triterpenoids, lignans, glycosides, and flavonoids have also been identified [these are described in a recent review by Ud-Din Khan and N. Parveen (75)]. 

Hashimoto, S, Honda, T, Ikegami, S, A new and general glycosidation method for podophyllum lignan glycosides. Tetrahedron Lett., 32, 1653-1654, 1991. 

Coniferin (20) is one of the most abundant lignan glycosides occurring mostly in coniferous trees and some other plants. It is the dominant transport and storage form of coniferyl alcohol, which in turn constitutes the main building block of lignins. 

GR Pettit, DE Sahaufelberger. Isolation and structure of the cytostatic lignan glycoside phyllanthostatin A. /Aaf Prorf 51 1104—1112, 1988. 

T Deyama, T Ikawa, S Nishibe. The constituents of Eucommia ulmoides Ohv n. Isolation and structures of three new lignan glycosides. Ghent Phamt Bull 33 3651-3657, 1985. 

The resin product obtained by extraction of the dried roots and rhizomes of the North American plant Podophyllum peltatum L. (the American mandrake or mayapple) and of the related Indian species Podophyllum emodi Wall. Ex Royle is known as podophyllin and has long been known to possess medicinal properties. The major active substance in podophyllin is the lignan lactone podophyllotoxin (7) although a variety of other lignans and lignan glycosides have also been isolated from podophyllin. ... 

The leaf-closing substance 79 has been isolated from a nyctinastic plant," and compound 80 is a new lignan glycoside isolated in tiny proportions from the roots of Saussurea lappa Xyloside 81 is a new glycoside isolated from the mycelia of Hericium erinaceum which contains compounds that stimulate nerve growth factor synthesis. Two derivatives were made by chemical transformations. 

Hansel and co-workers [77] have studied the lignan glycoside arctiin as a chemotaxonomic characteristic of the Compositae family. Arctiin sould be separated from arctigenin on silica gel G layers with ethyl acetate-methanol (95 + 5), the hi /-values being 23 and 77, respectively. Both yield red-violet coloms with antimony (III) chloride (Rgt. No. 15) or with concentrated sulphuric acid. 

With TLC and HPLC the authentication of Cortex Albiziae can be easily achieved based on the lignan glycosides. The triterpene oligosids are only present in very low concentration, therefore not suitable as marker compounds. 

Batirov E Kh, Matkarimov A D, Malikov V M, Yugudaev M R 1985 Versicoside - a novel lignan glycoside from Haplophyllum versicolor. Khim Prir Soedin 624-628... 

Deyama T, Ikawa T, Kitagawa S, Nishibe S 1986 The constituents of Eucommia ulmoides Oliv. III. Isolation and structure of a new lignan glycoside. Chem Pharm Bull 34 523-527... 

Medvedeva S A, Ivanova S Z, Babkin V A, Rezvukhin A I 1985 Volkova IV. Lignan glycoside from needles of Pinus sibirica. Khim Prir Soedin 560... 

A new lignan glycoside was also identified in the methanol extract of fruits of Comus kousa L. comuskoside A [Lee et al., 2008a], This compound is a xylopyranoside of dihydrodehydroconiferyl alcohol and was isolated for the first time from a natural source in these fruits. 

Kim K.S., Park S.H., Choung M.G. Nondestructive determination of lignans and lignan glycosides in sesame seeds by near infrared reflectance spectroscopy. Journal of Agricultural and Food Chemistry, 54 4544-4550 (2006). 

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