Podophyllum emodi

Proresid (mitopodozide), a mixture of more than 20 derivatives of Podophyllum emodi, has been used for many years in some countries as a disease-modifying agent in rheumatoid arthritis. A microtubuhn antagonist, it is comparable with colchicine and griseofulvin. Its use has been limited because treatment is often comphcated by severe diarrhea, abdominal pain, nausea, and vomiting. Leukopenia and thrombocytopenia have been reported (3,4). 

Podophyllum emodi Gentiana sp. But, 1994 Chan, 1997 Drew and Myers, 1997... 

P. notoginseng, P. zingerberensis Panax quinquefolius Eleuthrococcus senticosus Amorhophallus konjac Hydrastis canadensis Coptis chinensis Citrus paradisi Cyamopsis tetra-gonoloba Paullinia cupana Commiphora mukul Crategus monobyna Podophyllum emodi Datura metel Aesculus hippocastanum Ormosia coccinea Callilepsis laureola Juniperus spp. 

The resin product obtained by extraction of the dried roots and rhizomes of the North American plant Podophyllum peltatum L. (the American mandrake or mayapple) and of the related Indian species Podophyllum emodi Wall. Ex Royle is known as podophyllin and has long been known to possess medicinal properties. The major active substance in podophyllin is the lignan lactone podophyllotoxin (7) although a variety of other lignans and lignan glycosides have also been isolated from podophyllin. ... 

On the basis of the above spectoscopic studies, structure (8) was assigned to podorhizol which was isolated from the roots of Podophyllum emodi Wall, and... 

Indian Podophyllum Podophyllum emodi WALL. Berberidaceae MD 6%-12% resin with l%-4% podophyllotoxin, only traces of peltatines, berberine ... 

Podophyllum, Indian. Rhizome and roots of Podophyllum emodi Wall., Berberidaceae. Habit, Himalaya Mountains, Kashmir. Constit. 6-12% resin, 1-4% podo-phyllotoxin berbedne. 

Podophyllotoxin was extracted from Podophyllum emodi Wall. var. chinense Sprague. 2, 3, 4, 6- tetra- o- acetyl- P - D- ghlcopyrunose was prepared in our laboratory Pichloromethane, BF3 Et20, Trichloromethane, methanol, zinc powder, copper powder, aluminium powder, magnesium powder and tin powder were purchased from chemical store. 

Lignan from Podophyllum emodi rhizomes. Also isol. from P. peltatum, other P. spp., Diphylleia grayi, Callitris drummondii and Juniperus spp. Potent cytotoxin. Cell division inhibitor. Cryst. (Me2CO aq. or MeOH). Mp 117-118°. [ajj)" —101.3° (EtOH). 4 Crystal modifications reported. Mp s up to 188-189° have been reported for carefully dried samples. 

Ranuncul Ranuncul Berberid Podophyllum emodi BerPodeml... 

Extracts of the Himalayan shrub Podophyllum emodi have been used for the treatment of malignant diseases for over two thousand years [2j. Studies by American and Swiss workers on the constituents of this plant and the May apple. Podophyllum peltatum, have shown that podophyllotoxin (LVIa) and its D-glucoside (LVIb) possess antimitotic activity. Subsequent investigations have shown that podophyllotoxin and deoxypodophyllotoxin (LVIc) are... 

Podophyllum emodi has long been used in China as an anticancer drug and to treat snakebites, periodontitis, skin disorders, coughs, and intestinal parasites. The dried roots are traditionally used as a contact cathartic. 

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