Antimitotic, podophyllum

Condylox is the brand name of podofilox, an antimitotic drug that can be chemically synthesized or purified from the plant families Coniferae and Berberidaceae (e.g., species of Juniperus and Podophyllum). Condylox 0.5% solu-... 

Podophyllotoxin-related cyclolignans include the important antitumour antimitotic podophyllotoxin ((MD)Phe(Phe) ] C40L) from Podophyllum species (Podophyllaceae) that inhibits topoisomerase and binds to tubulin. Podophyllotoxin-related compounds with antimitotic, cytotoxic and antitumour activity include 4 -demethylpodophyllotoxin, 4 -demethyldeoxypodophyllotoxin and deoxypodophyllotoxin. A variety of other kinds of cyclolignans and polycyclic neolignans have been characterized. 

Podophyllum Antimitotic for venereal warts Podophyllum peltatum Mayapple... 

Podophyllum is a powerful skin irritant and antimitotic agent, widely used in the topical treatment of condylo-mata acuminata. The anticancer topoisomerase inhibitors, tenoposide and etoposide, are podophyUotoxins. 

Extracts of the Himalayan shrub Podophyllum emodi have been used for the treatment of malignant diseases for over two thousand years [2j. Studies by American and Swiss workers on the constituents of this plant and the May apple. Podophyllum peltatum, have shown that podophyllotoxin (LVIa) and its D-glucoside (LVIb) possess antimitotic activity. Subsequent investigations have shown that podophyllotoxin and deoxypodophyllotoxin (LVIc) are... 

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