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Pneumocystis proved infection

Efiornithine has been used in the chemotherapy and chemoprevention of some tumors, including glioblastoma and colorectal carcinoma in the presence of polyposis coU (4). It has been used in the treatment of malaria tropica, in AIDS, and in Pneumocystis proved infections, with varied success. It has also been approved for use in Trypanosoma gambiense (SED-12, 708) (5,6). [Pg.1207]

Immune reconstitution syndrome A syndrome characterized by fever and worsening of clinical symptoms of opportunistic infections or new symptoms occurring within weeks after starting antiretroviral therapy. This has been described for mycobacterial infections (Mycobacterium avium complex and Mycobacterium tuberculosis), Pneumocystis proved pneumonia, toxoplasmosis,... [Pg.1568]

Yersinia enterocolitica or Yersinia pseudotuberculosis, Pneumocystis proved (29), Staphylococcus aureus (128), Cunninghamella bertholletiae (127), and Rhizopus spp. have been involved. The diagnosis of these spontaneously rare infections may be even more difficult, because the deferoxamine-associated form can have an unusual and atypical course. [Pg.1064]

Blockade of tumor necrosis factor alfa impairs resistance to infections with intracellular pathogens such as mycobacteria, Pneumocystis proved. Listeria monocytogenes,... [Pg.1750]

Isolated reports of Candida esophagitis or Pneumocystis proved Pneumocystis carinii) infections in immunocompetent patients and the possible decrease in CD4-I- T cells with or without opportunistic infections in several HIV-infected patients (SED-13,1097) (379) suggest that unexpected immunosuppressive effects of interferon alfa can occur. An autoimmune destruction of CD4 cells in patients with a particular HLA haplotype has been proposed as a possible mechanism (380). One patient also had an acute and fatal acute precipitation of infection with Entamoeba histolytica (SEDA-22, 403). However, the available evidence is still very limited and no firm conclusion can be drawn on a possible association between interferon alfa treatment and a fall in CD4 cell count or an immunosuppressive effect. [Pg.1815]

In a single-arm, open, prospective study between 1990 and 1995 (before HAART) the prophylactic efficacy of Fansidar was evaluated in 95 HIV-infected patients with successfully treated Pneumocystis proved pneumonia and no history of Toxoplasma encephalitis (3). Patients took Fansidar with folinic acid (15 mg) twice weekly and were followed for a median of 19 (range 1-72) months. Five patients had a Pneumocystis relapse, but three had not taken their therapy. Of the 69 patients positive for. r. t. -Toxoplasma IgG antibodies, only one developed toxoplasma encephalitis after 50 months. A rash developed in 16 patients after a median of 3 weeks, and required withdrawal in six. Two developed Stevens-Johnson syndrome after three or four doses. There was no significantly increased risk of adverse reactions to Fansidar in patients with previous hypersensitivity reactions to co-tri-moxazole. The results of this study are of particular relevance to areas in which HAART is unavailable and where the antimalarial activity of Fansidar may confer additional benefit. [Pg.2985]

In an open prospective study in 95 HIV-infected patients with successfully treated Pneumocystis proved pneumonia, pyrimethamine + sulfadoxine (25/500 mg) was given twice weekly to prevent relapse (159). There were allergic skin reactions in 16 patients, resulting in permanent withdrawal in six. Two patients developed serious adverse reactions (Stevens-Johnson syndrome), both of whom had continued to take prophylaxis despite progressive hypersensitivity reactions. [Pg.3222]

Trimethoprim is fairly active against a variety of Grampositive cocci and Gram-negative rods. Established indications for co-trimoxazole are infections of the sinuses, ears, lungs, and urinary tract, and infections due to Salmonella, Nocardia, Brucella, Stenotrophomonas maltophilia, Pneumocystis proved, and Toxoplasma (1,6). Co-trimoxazole is also used in the treatment of Wegener s granulomatosis, for prevention of spontaneous bacterial peritonitis, and in patients with advanced HIV infection for the prophylaxis of opportunistic infections (1,6). [Pg.3510]

Among kidney transplant recipients, the 5%-10% who experienced immunological complications (acute then chronic graft rejection) and, as a consequence, were exposed to intense immunosuppressive therapy during the first year become more susceptible to developing opportunistic infections (Pneumocystis proved, Listeria monocytogenes, Nocardia asteroides. Cryptococcus neoformans or Aspergillus). Tberefore, it is extremely important to take preventive measures, i.e., vaccinations and prophylaxis. [Pg.91]


See other pages where Pneumocystis proved infection is mentioned: [Pg.1459]    [Pg.1027]    [Pg.2399]    [Pg.83]    [Pg.455]    [Pg.265]   
See also in sourсe #XX -- [ Pg.625 ]




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