Paget disease extramammary

Tumors that are characteristically strongly and diffusely positive include those of the salivary glands, lung, breast, ovary, endometrium, bladder, and thymus, as well as mesotheliomas, neuroendocrine tumors, pancreaticobili-ary adenocarcinomas, and the fibrolamellar variant of hepatocellular carcinoma. 33 CK7 is also typically expressed in tumor cells of mammary and extramammary Paget disease. 34... 

Meissner K, Riviere A, Haupt G, Toning T. Study of neu-protein expression in mammary Paget disease with and without underlying breast carcinoma and in extramammary Paget disease. Am J Pathol. 1990 137 1305-1309. 

FIGURE 13.6 Extramammary Paget disease of the skin (A) often demonstrates reactivity for gross cystic disease fluid protein-15 (B). 

C-erbB-2 expression and prognosis in sweat gland carcinomas. Extramammary Paget disease also may stain for c-erbB-2 ... 

Mayes DC, Patterson JW, Ramnani DM, Mills SE. Alpha-methylacyl coenzyme A racemase is immunoreactive in extramammary Paget disease. Am Clin Pathol. 2007 127 567-571. 

Urethral and periurethral gland adenocarcinoma (female) Villous adenoma and adenocarcinoma of the bladder Extramammary Paget disease of the male external genitalia Pleomorphic adenoma of the salivary glands (male) Carcinoma of the salivary glands (male)... 

Diaz de Leon E, Carcangiu ML, Prieto VG, et al. Extramammary Paget disease is characterized by the consistent lack of estrogen and progesterone receptors hut frequently expresses androgen receptor. Am J Clin Pathol. 2000 113 572-575. 

Armes JE, Lourie R, Bowlay G, et al. Pagetoid squamous cell carcinoma in situ of the vulva Comparison with extramammary Paget disease and nonpagetoid squamous cell neoplasia. Int J Gynecol Pathol. 2008 27 118-124. 

PDT using 5-aminolevulinic acid is an effective treatment for several conditions such as Bowen disease, subsets of basal cell carcinomas and actinic keratosis. Surgical resection is the first-choice therapy for extramammary Paget disease (EMPD), but extensive resection is highly invasive and recurrences are frequent. 

Paget disease occurs in mammary and extramammary (EM) forms. Paget disease of the breast is almost always indicative of an underlying breast carcinoma, whereas EM Paget disease may be an indicator of metastatic carcinoma. 

Ramachandra S, Gillette CE, Millis RR. A comparative immu-nohistochemical study of mammary and extramammary Paget s disease and superficial spreading melanoma, with particular emphasis on melanocytic markers. Virchows Arch. 1996 429 371-376. 

Battles OE, Page DL, Johnson JE. Cytokeratins, CEA, and mucin histochemistry in the diagnosis and characterization of extramammary Paget s disease. Am J Clin Pathol. 1997 108 ... 

Hitchcock A, Topham S, Bell J, et al. Routine diagnosis of mammary and extramammary Paget s disease a modern approach. Am J Surg Pathol. 1992 16 58-61. 

Lloveras B, Googe PB, Goldberg DE, et al. Estrogen receptors in skin appendage tumors and extramammary Paget s disease. Mod Pathol. 1991 4 487-490. 

Helm KF, Goellner JR, Peters MS. Immunohistochemical stains in extramammary Paget s disease. Am J Dermatopathol. 1992 14 402-407. 

Zeng HA, Cartun R, Ricci Jr A. Potential diagnostic utility of CDX-2 immunophenotyping in extramammary Paget s disease. Appl Immunohistochem Mol Morphol. 2005 13 342-346. 

Zhang C, Zhang P, Sung CJ, et al. Overexpression of p53 is correlated with stromal invasion in extramammary Paget s disease of the vulva. Hum Pathol. 2003 34 880-885. 

Glasgow BJ, Wen DR, Al-Jitawi S, et al. Antibody to S-100 protein aids the separation of pagetoid melanoma from mammary and extramammary Paget s disease. J Cutan Pathol. 1987 14 223-226. 

P. Becker-Wegerich, C. Fritsch, K.W. Schulte, M. Megahed, W. Neuse, G. Goerz, W. Stahl, T. Ruzicka (1998). Carbon dioxide laser treatment of extramammary Paget s disease guided by photodynamic diagnosis. Br. J. Dermatol., 138, 169-172. 

Whenever an unresolving balanitis is in progress, premalignant conditions should be taken into consideration, such as Queyrat erythroplasia, extramammary Paget s disease. Lichen planus and balanitis xerotica obliterans (Palacios et al. 2006). 

Kondo Y, Kashima K, Daa T, et al. The ectopic expression of gastric mucin in extramammary and mammary Paget s disease. Am J Surg Pathol. 2002 26 617-623. 

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