Platinum complexes 5-coordinate

Conners, T. A. Roberts, J. J. In Platinum Coordination Complexes in Cancer Chemotherapy Recent Results in Cancer Research , Springer-Verlag, New York, 1974, 48. 

Alkylating agents Nitrogen mustards (cyclophosphamide) Busulphan Platinum coordination complexes (cisplatin) Nitrosoureas Crosshnks DNA strands... 

Roberts JJ. IN Platinum Coordination Complexes in Cancer Chemotherapy. Springer-Verlag Heidelberg, 1974 pp. 79-97. 

Rosenberg B. Platinum coordination complexes in cancer chemotherapy. Naturwissenschaften 1973 ... 

Eastman A, Richon VM. Mechanisms of cellular resistance to platinum coordination complexes. In (McBrien DCH, Slater TF, eds) Biochemical Mechanisms of Platinum Anticancer Drugs 1986 IRL Oxford, UK pp. 91-119. 

Calvert AH, Harland SJ, Harrap KR, Wiltshaw E, Smith IE. JM8 development and clinical projects. In (Hacker MP, Douple EB, Krakoff IH, eds), Platinum Coordination Complexes in Cancer Chemotherapy 1984 Martinus-Nijhoff Boston, pp. 240-252. 

Heavy metal compounds used to treat cancer include cisplatin, carboplatin, and oxaliplatin (see Table 36-6). These drugs, which contain platinum, are also known as platinum coordination complexes.10,27 Heavy metal drugs act like the alkylating agents that is, they form strong cross-links between and within DNA strands,... 

NCI-H460 and T47D), and all were more active than cisplatin. Given the success enjoyed by cisplatin-like platinum coordination complexes, this appears to be a promising area of research. 

Casini A, Gabbiani C, Michelucci E, Pieraccini G, Moneti G, Dyson PJ, Messori L (2009) Exploring metallodrug-protein interactions by mass spectrometry comparisons between platinum coordination complexes and an organometallic ruthenium compound. J Biol Inorg Chem 14 761-770... 

D. P. Kelsen, H. Scher, J. Burchenal, Phase I and Early Phase II Trials of 4 -Carboxyphthalato(l,2-Diaminocyclohexane)Platinum(II), in Platinum Coordination Complexes in Cancer Chemotherapy , Eds. M. P. Hacker, E. B. Douple, I. H. Krakoff, Martinus Nijhoff, Boston, 1984, p. 310. 

Cisplatin [SIS pla tin] is a member of the platinum coordination complex class of anticancer drugs. Because of cisplatin s severe toxicity, carboplatin [KAR bow pla tin] was developed. The therapeutic effectiveness of the two drugs is similar but their pharmacokinetics, patterns of distribution and dose-limiting toxicities differ. Cisplatin has synergistic cytotoxicity with radiation and other chemotherapeutic agents. 

Platinum coordination complexes have been investigated as potential anticancer agents since 1972. The most successful of these is the cis dichlor-diammine platinum(II) complex which is particularly effective for the treatment of ovarian and testicular carcinomas. However, effective therapy requires high doses, typically 4.0/umol (825/ig)kg-1 given intravenously, which produce unpleasant and toxic reactions. Pharmaco-kinetic studies of the various Pt species in plasma indicate that the active species is of low molecular weight and the protein bound Pt species is apparently inactive [106]. Further work is needed to identify the active species and to develop therapeutic procedures that produce maximum anti-tumour activity with minimum toxicity. 

Ghadially EN, Lock CJL, Yang-Steppuhn SE, Lalonde JMA. Platinosomes produced in cultured cells by platinum coordination complexes. J. Submicrosc. Cytol. 1981 13 223-230. 

Ghadially EN, Lock CJL, Lalonde JMA, Ghadially R. Platinosomes produced in synovial membrane by platinum coordination complexes. Virchows Arch., B, Cell Pathol. 1981 35 123-131. Beretta GL, Righetti SC, Lombardi L, Zunino F, Perego P. Electron microscopy analysis of early localization of cisplatin in ovarian carcinoma cells. Ultrastruct. Pathol. 2002 26 331-334. Ruben GC. Ultrathin (Inm) vertically shadowed platinum-carbon replicas for imaging individual molecules in freeze-etched biological DNA and material science metal and plastic specimens. J. Electron. Microsc. Tech. 1989 13 335-354. 

Swiss pharmaceutical company Roche. It is a new platinum anticancer drug, result of a trinuclear platinum coordination complex with chloride and amine ligands. It is active through covalent adducts with DNA inducing apoptosis. 

Trosko, J.E. in "Platinum Coordination Complexes in Cancer Chemotherapy. Recent Results in Cancer Research, vol. 48", Springer-Verlag, Berlin, 1974, p.l08. 

Carboplatin is a platinum coordination complex that produces predominantly interstrand DNA cross-links causing... 

P.J. Sadler, M. Nasr and V.L. Narayanan, in Platinum Coordinate Complexes in Cancer Chemotherapy, eds. M.T. Hackler, I. Krakoff and E.B. Dauple (Martinus Nijhoff, Boston, MA, November 1983) pp. 290-304. 

---