Plaque inhibition

Extracts that exhibited significant inhibitory activity, defined as >50% inhibition of CPE at 100 (xg/mL, were advanced into secondary screening, which includes confirmation of activity observed during the primary screen using an expanded range of concentrations (dose response), plaque inhibition assay, and a one-step growth inhibition and testing of additional influenza viruses. As shown in Fig. 1.2a, the quantitative dose response assay was used to assess the potency of the most two... 

A mixture of essential oils consisting of thymol 0.06%, eucalyptol 0.09%, methyl salicylate 0.06%, and menthol 0.04% in an alcohol-based vehicle (26.9%) provides the plaque-inhibiting properties of rinsing agents such as Listerine. 

A few well-controlled clinical studies suggested a potential plaque-inhibiting effect for dentifrices containing staimous fluoride. However, these results were most likely due to the stannous ion rather than to fluoride the positive charge of the stannous ion may interfere with bacterial membrane function, bacterial adhesion, and glucose uptake, thereby inhibiting the formation of plaque. 

Mild tooth staining has been observed after use of stannous fluoride products. The ADA Council on Dental Therapeutics endorses fluorides for their caries-inhibiting effect but not for plaque inhibition. 

Bonosvoll P, Gjermo P. A comparison between chlorhexedine and some quaternary ammonium compounds with regard to retention, salivary concentration and plaque-inhibiting effect in the human mouth after mouth rinses. Arch Oral Biol 1978 23 289-294. 

Sensitivity of passaged virus to drug is then determined in a plaque inhibition assay, in a microtiter CPE inhibition assay in liquid culture, or in a yield reduction assay. 

Primary screening for antiviral activity was carried out using the agar-diffusion plaque-inhibition method with cylinders [65]. The compounds were tested against one representative in each of the four taxonomic viral groups namely, picoma-, orthomyxo-, paramyxo- and herpes viruses, which represent a few of the most important families of the human patogens. The viruses used were poliovirus 1 (PV1), influenza virus A (FPV), Newcastle disease virus (NDV) and pseudorabies virus (PsRV). 

Medical Wound and bone healing, blood cholesterol control, skin burn, contact lens, surgical sutures, dental plaque inhibition, clotting agent, etc. 

Plaque inhibition or reduction assays Only for viruses which form plaques in suitable cell systems. Titration of a limited viruses number or residual viruses infectivity after extracellular action of the tested compound. The tested compound must be in a non-toxic dose or cytotoxicity should be eliminated by dilution or filtration before the titration. 

Multiple sclerosis The 150-kDa calpain specific degradation product of a-spectrin increases 50% in human MS plaques.44 Degradation of the 68-kDa neurofilament protein is inhibited by a synthetic calpain inhibitor45... 

Cranberry juice has long been recommended for use in treating and preventing urinary tract infections (UTIs). Clinical studies have confirmed that cranberry juice is beneficial to individuals with frequent UTIs Cranberries inhibit bacteria from attaching to the walls of the urinary tract and prevent certain bacteria from forming dental plaque in the mouth. Cranberry juice is safe for use asa food and for urinary tract health. Cranberry juice and capsules have no contraindica-tions no known adverse reactions and no drug interactions The recommended dosage is9 to 15 capsules a day (400-500 mg/d) or 4 to 8 ounces of juice per day. (See Chap. 6 for more information.)... 

Bea F, Blessing E, Bennett BJ, et al. Chronic inhibition of cyclooxygenase-2 does not alter plaque composition in a mouse model of advanced unstable atherosclerosis. Cardiovasc Res 2003 60(1) 198-204. 

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