Pituitary adenylate cyclase-activating peptide PACAP

J (339), a 28-amino acid peptide, is a member of a family of stmctuially related peptides that includes secretin [1393-25-5] (340), growth hormone releasing factor (GRF), and pituitary adenylate cyclase-activating peptide (PACAP) [137061(341) (83). 

Zhang XC, Zhang YQ, Zhao ZQ (2005) Involvement of nitric oxide in long-term potentiation of spinal nociceptive responses in rats. NeuroReport 16 1197-1201 Zhang Y, Malmberg AB, Sjolund B, Yaksh TL (1996) The effect of pituitary adenylate cyclase activating peptide (PACAP) on the nodceptive formalin test. Neurosci Lett 207 187-190... 

Peptide neurotransmitters and hormones are collectively termed neuropeptides. Neuropeptides typically consist of small peptides of approximately 3 0 residues. Several neuropeptides and several of their regulatory functions are listed these neuropeptides and others function in multiple roles as physiological regulators (too numerous to hst in this short table). Ahhreviations are adrenocorticotropin hormone (ACTH), a-melanoc)de stimulating hormone (a-MSH), neuropeptide Y (NPY), and pituitary adenylate cyclase-activating peptide (PACAP). 

Finally, peptides such as galanin, leptin, neuropeptide Y, vasoactive intestinal polypeptide (VIP), and pituitary adenylate cyclase-activating polypeptide (PACAP) have been identified in various areas of the CNS. These and other peptides may affect various CNS functions, either by acting directly as neurotransmitters or by acting as cotransmitters moderating the effects of other neurotransmitters.7 24,27,34... 

PCAP pituitary adenylate cyclase-activating peptide. PCAP(6-38) (pituitary adenylate cyclase-activating peptide (6-38)(human, ovine, rat)) is an antagonist of PCAP, a VASOACTIVE INTESTINAL PEPTIDE RECEPTOR ANTAGONIST with highest affinity at the PACAP subtype. 

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